Protein Alignment TyrR and TAAR5

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_003958.2
• Gene: TAAR5 / 9038
• HGNCID: 30236
• Length: 337
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 117/559 - (20%)
• Similarity: 170/559 - (30%)
• Gaps: 266/559 - (47%)

  Fly    95 YNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLA 159
            |..:.:.....|    .|..|.:|.:|..|..::: |:||..|..|:...:.|.|.||..::|||
Human    18 YQVNGSCPRTVH----TLGIQLVIYLACAAGMLII-VLGNVFVAFAVSYFKALHTPTNFLLLSLA 77

  Fly   160 VADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY 224
            :||:.:|:.|:|.:....:...|..|..||.:...||.|.|..||..||.||:||:.|:..||.|
Human    78 LADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLY 142

  Fly   225 SRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQ---------------NE- 273
            ..| .:.|:||..||..|.:..|.|   .|..|    .|:.|.|.:|               |:
Human   143 PSK-FTVRVALRYILAGWGVPAAYT---SLFLY----TDVVETRLSQWLEEMPCVGSCQLLLNKF 199

  Fly   274 -GYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQH 337
             |::.|..   ||:|..:||.:|.:| .|:|:|
Human   200 WGWLNFPL---FFVPCLIMISLYVKI-FVVATR-------------------------------- 228

  Fly   338 SSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLAL 402
                |.|:
Human   229 ----QAQQ--------------------------------------------------------- 232

  Fly   403 PSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQ 467
                                              |||:
Human   233 ----------------------------------ITTL--------------------------- 236

  Fly   468 THSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSL 532
                                                                  ||||:.   :.
Human   237 ------------------------------------------------------SKSLAG---AA 244

  Fly   533 KKENKTTQTLSIVVGGFIACWLPFFIN-------YLITPFLAEHQASQMLAKALTWLGWFNSAIN 590
            |.|.|..:||.|.||.::.|||||.|:       :.|||        .::.....|..:||||.|
Human   245 KHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITP--------PLVFDIFIWFAYFNSACN 301

  Fly   591 PFIYAFYSVDFRAAFWRLTCKRFFSAGQKPQFPTNTMSI 629
            |.||.|....||.|......::.||    ||  |.|:.:
Human   302 PIIYVFSYQWFRKALKLTLSQKVFS----PQ--TRTVDL 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	66/202 (33%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	14/29 (48%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/26 (35%)
		7tm_GPCRs	<533..605	CDD:475119	29/78 (37%)
		TM helix 6	539..561	CDD:320189	11/28 (39%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
TAAR5	NP_003958.2	7tmA_TAAR5	35..316	CDD:320441	106/512 (21%)
		TM helix 1	36..62	CDD:320441	8/26 (31%)
		TM helix 2	69..95	CDD:320441	10/25 (40%)
		TM helix 3	107..137	CDD:320441	14/29 (48%)
		TM helix 4	149..172	CDD:320441	10/29 (34%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	176..189		3/12 (25%)
		TM helix 5	196..225	CDD:320441	10/32 (31%)
		TM helix 6	245..275	CDD:320441	14/29 (48%)
		TM helix 7	284..309	CDD:320441	10/24 (42%)