DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Chrm2

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_112278.2 Gene:Chrm2 / 81645 RGDID:620023 Length:466 Species:Rattus norvegicus


Alignment Length:541 Identity:136/541 - (25%)
Similarity:222/541 - (41%) Gaps:133/541 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVH 177
            :::.:.::.|..:..:||:|||.||:::|...|.|:|:.|.|:.|||.|||::|:|.|.......
  Rat    20 TFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYT 84

  Fly   178 LIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVW 242
            :||.|.||.|:||:|::||.::..||:::|..||.|||..||:||||..||.:| :|.:||...|
  Rat    85 VIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTK-MAGMMIAAAW 148

  Fly   243 LLALAITCPPMLGW-YEPGRRDLR--EC--RYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVI 302
            :|:..:..|.:|.| :..|.|.:.  ||  ::..|......:|:.:|::|:.:|..:|..||...
  Rat   149 VLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRAS 213

  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367
            .||          .||.|:...|:                  :...|.:.....|.|...:.|  
  Rat   214 KSR----------IKKEKKEPVAN------------------QDPVSPSLVQGRIVKPNNNNM-- 248

  Fly   368 DSDNCAAMGAGGAGGGGGGA--SSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA 430
                         .||.||.  :....|       ..|..||       ...|.:    ...|.:
  Rat   249 -------------PGGDGGLEHNKIQNG-------KAPRDGV-------TENCVQ----GEEKES 282

  Fly   431 STASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSH 495
            |..||:::.:.|.|                      :...::|...|.|....|...|..:    
  Rat   283 SNDSTSVSAVASNM----------------------RDDEITQDENTVSTSLGHSRDDNSK---- 321

  Fly   496 HHHPHYHHQAGV------------TTTSTS----GNTSANTNSKS--LSNRITSLKK-------- 534
                    |..:            |.|||:    |::..|.:.|.  ::.:|..:.|        
  Rat   322 --------QTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPP 378

  Fly   535 ---ENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAF 596
               |.|.|:|:..::..||..|.|:.:..||..|.|....:.:..... ||.:.||.|||..||.
  Rat   379 PSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGY-WLCYINSTINPACYAL 442

  Fly   597 YSVDFRAAFWRLTCKRFFSAG 617
            .:..|:..|..|....:.:.|
  Rat   443 CNATFKKTFKHLLMCHYKNIG 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 71/190 (37%)
TM helix 1 118..144 CDD:320189 9/25 (36%)
TM helix 2 151..177 CDD:320189 11/25 (44%)
TM helix 3 189..219 CDD:320189 13/29 (45%)
TM helix 4 232..255 CDD:320189 6/22 (27%)
TM helix 5 272..297 CDD:320189 6/24 (25%)
7tm_GPCRs <533..605 CDD:475119 23/82 (28%)
TM helix 6 539..561 CDD:320189 6/21 (29%)
TM helix 7 573..598 CDD:320189 9/24 (38%)
Chrm2NP_112278.2 7tmA_mAChR_M2 24..451 CDD:320424 133/523 (25%)
TM helix 1 25..51 CDD:320424 9/25 (36%)
TM helix 2 58..84 CDD:320424 11/25 (44%)
TM helix 3 96..126 CDD:320424 13/29 (45%)
Important for signaling 120..122 1/1 (100%)
TM helix 4 138..161 CDD:320424 7/23 (30%)
TM helix 5 183..212 CDD:320424 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..289 21/121 (17%)
TM helix 6 380..410 CDD:320424 9/29 (31%)
TM helix 7 419..444 CDD:320424 9/25 (36%)
Important for signaling 436..440 2/3 (67%)

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