Protein Alignment TyrR and Htr1f

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_068629.2
• Gene: Htr1f / 60448
• RGDID: 71083
• Length: 366
• Species: Rattus norvegicus
• Alignment Length: 496
• Identity: 125/496 - (25%)
• Similarity: 202/496 - (40%)
• Gaps: 155/496 - (31%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            |::....:...::|...|:|||.||:.||:|....|..:.||||.|.||.:.|||.::...:..|
  Rat    24 ILVSLTLSGLALMTTTINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVSES 88

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |.:|..|||:|:|:|::.|:.|||.|.||::|||.|:|..:.|:|| |:.|.|.|.|..||::::
  Rat    89 WIMGQGLCDLWLSVDIICCSCSILHLSAIALDRYRAITDAVEYARK-RTPRHAGITITTVWVISV 152

  Fly   247 AITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTD 311
            .|:.||:...::...||.:....:.:....|:|..|:|:||:.:::.:|
  Rat   153 FISMPPLFWRHQGNSRDDQCIIKHDHIVSTIYSTFGAFYIPLVLILILY---------------- 201

  Fly   312 ISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMG 376
                   :|.|.||             .....:|||      ::.|.:||...:|.:|..
  Rat   202 -------YKIYRAA-------------RTLYHKRQA------SRMIKEELNGQVLLESGE----- 235

  Fly   377 AGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMT 441
                                                            .|:|..||
  Rat   236 ------------------------------------------------KSIKLVST--------- 243

  Fly   442 SGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAG 506
                  |.:|:                .|||.|.......||..:..|..|:
  Rat   244 ------SYMLE----------------KSLSDPSTDFDRIHSTVKSPRSELK------------- 273

  Fly   507 VTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQA 571
                          :.||...:..|..:|.|...||.:::|.|:.||||||:..|:.....:.:.
  Rat   274 --------------HEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNICEKCKI 324

  Fly   572 SQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLT-CK 611
            |:.::..|.|||:.||.|||.||..::.||:.||.:|. |:
  Rat   325 SEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	64/185 (35%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	7/24 (29%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Htr1f	NP_068629.2	7tmA_5-HT1F	24..359	CDD:320456	122/488 (25%)
		TM helix 1	25..51	CDD:320456	7/25 (28%)
		TM helix 2	58..84	CDD:320456	11/25 (44%)
		TM helix 3	96..126	CDD:320456	16/29 (55%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	9/21 (43%)
		TM helix 5	178..207	CDD:320456	9/51 (18%)
		TM helix 6	286..316	CDD:320456	13/29 (45%)
		TM helix 7	326..351	CDD:320456	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)