Protein Alignment TyrR and HRH4

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_067637.2
• Gene: HRH4 / 59340
• HGNCID: 17383
• Length: 390
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 105/507 - (20%)
• Similarity: 191/507 - (37%)
• Gaps: 150/507 - (29%)

  Fly   112 LSWQGIILIAVFATFIVVTV-IGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVA 175
            ||....:.:|.|.:.:...: :||.|||||.:..:.||..::.|.::||::|..||:..:|..:.
Human    10 LSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIP 74

  Fly   176 VHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILI 240
             |.:..|..|..:|..|::.|.||||||:.::..||.||||:|:..::| |.:.:..|.::.:::
Human    75 -HTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSY-RTQHTGVLKIVTLMV 137

  Fly   241 -VWLLALAITCPPML---GWYEPGRRDLRECRYN-QNEGYVI-FSAMGSFFIPMAVMIYVYARIS 299
             ||:||..:..|.:|   .|.:.|    .||... .:|.|:: .::...|.||:.::.|.
Human   138 AVWVLAFLVNGPMILVSESWKDEG----SECEPGFFSEWYILAITSFLEFVIPVILVAYF----- 193

  Fly   300 CVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDM 364
                       :::::...:||       :.||..:.|..:..........:|..:
Human   194 -----------NMNIYWSLWKR-------DHLSRCQSHPGLTAVSSNICGHSFRGR--------- 231

  Fly   365 MLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKR 429
             ||...:.:|            ::......|.:                      ...|.|||..
Human   232 -LSSRRSLSA------------STEVPASFHSE----------------------RQRRKSSLMF 261

  Fly   430 ASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRS 494
            :|.......|:.|.||..|             |:..|..|.                      |.
Human   262 SSRTKMNSNTIASKMGSFS-------------QSDSVALHQ----------------------RE 291

  Fly   495 HHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFIN 559
            |                                  ..|.:..:..::|:|::|.|..||.|:.:.
Human   292 H----------------------------------VELLRARRLAKSLAILLGVFAVCWAPYSLF 322

  Fly   560 YLITPFLAEHQASQML-AKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC 610
            .::..|.:.....:.: .:...||.||||.:||.:|......|:.||.::.|
Human   323 TIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFC 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	56/192 (29%)
		TM helix 1	118..144	CDD:320189	9/26 (35%)
		TM helix 2	151..177	CDD:320189	7/25 (28%)
		TM helix 3	189..219	CDD:320189	15/29 (52%)
		TM helix 4	232..255	CDD:320189	7/26 (27%)
		TM helix 5	272..297	CDD:320189	6/25 (24%)
		7tm_GPCRs	<533..605	CDD:475119	18/72 (25%)
		TM helix 6	539..561	CDD:320189	7/21 (33%)
		TM helix 7	573..598	CDD:320189	9/25 (36%)
HRH4	NP_067637.2	7tmA_Histamine_H4R	16..374	CDD:320422	102/499 (20%)
		TM helix 1	17..43	CDD:320422	9/25 (36%)
		TM helix 2	50..77	CDD:320422	8/27 (30%)
		TM helix 3	87..117	CDD:320422	15/29 (52%)
		TM helix 4	132..150	CDD:320422	4/17 (24%)
		TM helix 5	171..201	CDD:320422	6/45 (13%)
		TM helix 6	296..326	CDD:320422	7/29 (24%)
		TM helix 7	337..362	CDD:320422	9/24 (38%)