Protein Alignment TyrR and htr6

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_009295353.2
• Gene: htr6 / 568269
• ZFINID: ZDB-GENE-030131-7839
• Length: 540
• Species: Danio rerio
• Alignment Length: 579
• Identity: 136/579 - (23%)
• Similarity: 214/579 - (36%)
• Gaps: 231/579 - (39%)

  Fly    95 YNESAAAAE-WAHFYDLVLSWQGIILIAVFATFIV-VTVIGNTLVILAILTTRRLRTITNCFVMS 157
            :|:|:..:: |:      :...|..|:||..:.|: ||..||.|:|..:...|.||..:|||::|
Zfish    92 FNDSSTISDGWS------IGGSGPWLLAVMLSLIILVTACGNILLIALVFAHRSLRCTSNCFLVS 150

  Fly   158 LAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPL 222
            |.::||:|.:.|||||:...|.|:|.|....|.:|:..||:.|:||||:||.||:||||.:..||
Zfish   151 LFLSDLMVALVVMPPAMLNVLCGTWVLAPGFCPVWLCFDVMCCSASILNLCVISLDRYLLIISPL 215

  Fly   223 TYSRKRRSKRLALIMILIVW-LLALAITCPPMLGWYEPGR-RDLRE------------------- 266
            .|.:.....| ||:::...| |.||....|..:.|:..|| ::|.|
Zfish   216 RYKQHMTPPR-ALLLVGGAWGLAALTSFLPIKMDWHSLGRMQELTEDDPGNATHLNSFYPSSYFQ 279

  Fly   267 ----------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKR 321
                      ||......:.:.:...:||:|...:.:.|.||  ::|:|
Zfish   280 LSSSGMPSTQCRLRVTLPFALVATFLTFFLPSTAICFTYCRI--LLAAR---------------- 326

  Fly   322 YTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGG 386
                                   ||           |::::.:
Zfish   327 -----------------------RQ-----------ARQVEAL---------------------- 335

  Fly   387 ASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLL 451
                   ||    .|.|...:|           |.:||.|                   ||.::.
Zfish   336 -------TH----PAYPQHSLG-----------EPSRPPS-------------------PGHAIQ 359

  Fly   452 DAQWQS--QPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSG 514
            |....|  :|||                  .||:....:.||..:|...
Zfish   360 DGDDYSHQEPPG------------------LRHAPLSVNSERRLAHRQR---------------- 390

  Fly   515 NTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYL-------ITPFLAEHQAS 572
                              |:..|.:.||.:::|.|.:.||||||..:       :.|...:
Zfish   391 ------------------KRALKASLTLGVLLGLFFSAWLPFFITNMAQAVCECVPPSFFD---- 433

  Fly   573 QMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL--TCKRFFSAGQKPQFPTNTMSI 629
                 |:||||:.||.:||.||..:..||:.|..||  .|    |:.|.|:.|:..:|:
Zfish   434 -----AITWLGYCNSTMNPIIYPMFMRDFKRALARLLPCC----SSSQAPRRPSLPLSL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/217 (33%)
		TM helix 1	118..144	CDD:320189	10/26 (38%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	8/23 (35%)
		TM helix 5	272..297	CDD:320189	4/24 (17%)
		7tm_GPCRs	<533..605	CDD:475119	26/78 (33%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
htr6	XP_009295353.2	None