Protein Alignment TyrR and drd1b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001129448.1
• Gene: drd1b / 568126
• ZFINID: ZDB-GENE-070524-2
• Length: 446
• Species: Danio rerio
• Alignment Length: 509
• Identity: 129/509 - (25%)
• Similarity: 194/509 - (38%)
• Gaps: 214/509 - (42%)

  Fly   118 ILIAVFATFIVV-TVIGNTLVILAILTTRRLRT-ITNCFVMSLAVADLLVGIFVMPPAVAVHLIG 180
            :|...|.:.::: |::|||||..|:...|.||: :||.||:|||::||||.|.|||...|..::|
Zfish    22 VLTGCFLSLLILTTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAISDLLVAILVMPWKAATEIVG 86

  Fly   181 SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLA 245
            .|..| ..||:|::.|::..|||||:||.||||||.|::.|..|.||...| :|.|||.:.|.|:
Zfish    87 FWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPK-VAFIMISVAWTLS 149

  Fly   246 LAIT-CPPMLGWYEPGRRDLRE------------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYAR 297
            :.|: .|..|.|::.......|            |..:.|..|.|.|::.||:||:|:|:..|.|
Zfish   150 ILISFIPVQLNWHKAQTTSYTELNGTYGELPPDNCDSSLNRTYAISSSLISFYIPVAIMLVTYTR 214

  Fly   298 ISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQ 362
            |                                       ..:.|:|
Zfish   215 I---------------------------------------YRIAQKQ------------------ 222

  Fly   363 DMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSL 427
                                                                      :.|.|:|
Zfish   223 ----------------------------------------------------------IRRISAL 229

  Fly   428 KRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL 492
            :||:                                                          |..
Zfish   230 ERAA----------------------------------------------------------ESA 236

  Fly   493 RSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFF 557
            ::.|              |:.||   |.:.:|.|:...|.|:|.|..:|||:::|.|:.||||||
Zfish   237 KNRH--------------SSMGN---NASMESESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFF 284

  Fly   558 INYLITPFLAEHQASQMLAKALT------WLGWFNSAINPFIYAFYSVDFRAAF 605
            :...:.||...::::..|..:.|      |.||.||::||.|||| :.|||.||
Zfish   285 VLNCMVPFCNPNESTDFLCISSTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	79/200 (40%)
		TM helix 1	118..144	CDD:320189	9/26 (35%)
		TM helix 2	151..177	CDD:320189	16/25 (64%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	8/23 (35%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	32/77 (42%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	13/30 (43%)
drd1b	NP_001129448.1	7tm_GPCRs	21..337	CDD:475119	127/507 (25%)
		TM helix 1	24..48	CDD:320443	8/23 (35%)
		TM helix 2	58..80	CDD:320443	14/21 (67%)
		TM helix 3	95..117	CDD:320443	11/21 (52%)
		TM helix 4	140..156	CDD:320443	6/15 (40%)
		TM helix 5	190..213	CDD:320443	9/22 (41%)
		TM helix 6	266..288	CDD:320443	11/21 (52%)
		TM helix 7	306..331	CDD:320443	12/25 (48%)