Protein Alignment TyrR and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 918
• Identity: 204/918 - (22%)
• Similarity: 307/918 - (33%)
• Gaps: 354/918 - (38%)

  Fly     5 LQLNNLSAI-YPSLMYVAASSSSLRGLGLGSGVG--VGGL---PENISIV-YEDAGNGTGGGGVG 62
            :|...||:: :||......::.:|.|..:|.||.  .|||   |.....| |....|.||.....
Mosquito    22 VQFVRLSSVPFPSPHLSGTATVTLAGATVGVGVRGLAGGLVRPPAYTGYVSYMKQFNFTGNPIDN 86

  Fly    63 GVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFI 127
            ..|.....||:..||....:.|  :.:...||                   |..:.:|.||.
Mosquito    87 RTGAEAGLGPDRIDADDDEDDG--SSLALHNY-------------------WALLAIILVFG--- 127

  Fly   128 VVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIW 192
              |..||.||.|||:..|||:.:||.|:||||:.||:|.:.|||..:...:.|.:.|....|.:|
Mosquito   128 --TAAGNILVCLAIVWERRLQNVTNYFLMSLAITDLMVALSVMPLGILTLVKGHFPLDSEYCLVW 190

  Fly   193 ISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWY 257
            |.||||.|||||:.||.|||||||::..|:.:.|.:..:|:.| .|..||||::|::.|..|
Mosquito   191 ICLDVLFCTASIMHLCTISVDRYLSLRYPMKFGRNKTRRRVVL-KISFVWLLSIAMSLPLSL--- 251

  Fly   258 EPGRRDLRECRYNQNEGYV-----------IFSAMGS---FFIPMAVMIYVYARISCVIASRHDN 308
                      .|::|...|           ::..:||   |:||:.||:..|.....::|.:.:|
Mosquito   252 ----------MYSKNHASVLVDGTCQIPDPVYKLVGSIVCFYIPLCVMLITYTLTVRLLAQQSEN 306

  Fly   309 MTDISV----------------HNKKFKR--------------YTAADVENELSEQEQH------ 337
            :..:..                ....:||              ::||..:.|||..:.|
Mosquito   307 LGGVGSGGGWSSGWLGQAPAFDRRNTWKRIIKLSLPAAQNPHAHSAASTDTELSTLDNHDLWLLE 371

  Fly   338 ----------------------------SSVGQ------------------------RQRQATS- 349
                                        .||.|                        |::.|.:
Mosquito   372 SSIPEPSSITMTAMQRFGEEMLKLSQGLESVAQHSDRNSGQNGSSRSPEPSREKESFRKKPANAK 436

  Fly   350 --------------------RTFSNQTIAKE---------------------------------- 360
                                |:.::..||:.
Mosquito   437 HAPTPVTMVTVRSPVPSKKRRSSTSTWIARRNSGTPPPVRLVRKRFKSLPHALPPPASDDIEVDE 501

  Fly   361 --LQDMM--LSDSD-------NCAAMGAGGAGGGGGGASSAT-------------GGTHCQSLLA 401
              :||::  |.|.:       :.|..||.|..|....||.||             .|......||
Mosquito   502 QFMQDVLYELRDREDRGSVHGSSARPGAAGLDGVPAAASRATSDRREGRDAGSNPAGPRQAHPLA 566

  Fly   402 LPS-------------------GGVG-------------------GSM-GCAKNG---CYELTRP 424
            .||                   |..|                   |.| |.|.||   .|.....
Mosquito   567 APSQTAATLKLPPPCKCPFFGEGAPGRQQYLRPAEIKIVKTSTDFGPMGGAASNGDSLVYSTISI 631

  Fly   425 SSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPP----------------------GQTGQVQ 467
            ||....:|..|...:.:....|.|:|.....:...|                      .:|..:.
Mosquito   632 SSGSNVTTQPTRSISSSLSTLPASALASPSRKGSAPKGISVVTWDQRRHQRRGSSFGGARTSLLL 696

  Fly   468 THSLSQPP-----RTHSFRHSHGERD-------------RERLRSHHHHP-HYHHQAG------- 506
            |.:.:.|.     |:.:.|||..|..             |...:.:...| ...||.|
Mosquito   697 TPTKASPSSVSLRRSINLRHSALEGGGGGGGGSAGETMFRGAPKKNSSSPCLMQHQTGGGGGGGA 761

  Fly   507 ------------------------VTTTST-----SGNTSANTNSKSLSNRITSLKKENKTTQTL 542
                                    .|||..     |.|:|..:.:.|...||  ::.|.|.|:.|
Mosquito   762 VGGGNGTAVAMMAVAAASSTVPTLATTTMAVRSHHSRNSSMISRNSSRHGRI--IRLEQKATKVL 824

  Fly   543 SIVVGGFIACWLPFFINYLITPFLAEH---QASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAA 604
            .:|...|:..|.|||:..|: |.:.:|   ...|.:.:.:||||:.:|.:||..|..::..||.|
Mosquito   825 GVVFFTFVILWAPFFVLNLL-PSVCKHCEDNIDQWVFEFVTWLGYASSLVNPIFYTIFNKAFRDA 888

  Fly   605 FWR-LTCK 611
            |.: |.|:
Mosquito   889 FRKVLLCR 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	73/199 (37%)
		TM helix 1	118..144	CDD:320189	11/25 (44%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	21/29 (72%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	10/38 (26%)
		7tm_GPCRs	<533..605	CDD:475119	24/74 (32%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
5-HT2B	XP_061501050.1	None