Protein Alignment TyrR and adrb2a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001096122.1
• Gene: adrb2a / 565838
• ZFINID: ZDB-GENE-100414-3
• Length: 405
• Species: Danio rerio
• Alignment Length: 506
• Identity: 115/506 - (22%)
• Similarity: 176/506 - (34%)
• Gaps: 206/506 - (40%)

  Fly   115 QGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI 179
            |..:|..:.:..:::.|.||.:||.||...:||:.:||||:.|||.|||::|:.|:|......::
Zfish    27 QMTVLGTLMSILVLIIVFGNVMVITAISRFQRLQNVTNCFITSLACADLVMGLVVIPFGALYIIL 91

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLL 244
            .:|..|..|||.|.:.|||..||||.:||.|::|||:|:|.|..| :...:|..|..::|:||::
Zfish    92 NTWHFGHFLCDFWTATDVLCVTASIETLCVIAMDRYIAITSPFRY-QSLLTKNRARFIVLMVWVI 155

  Fly   245 ALAITCPP--MLGWYEPGRRDLRECRYNQ--------NEGYVIFSAMGSFFIPMAVMIYVYARIS 299
            |..::..|  |..|.......|  |.||.        ...|.|.|::.||:||:.:|::||:|:.
Zfish   156 AGLVSYLPIHMEWWISTDNETL--CCYNNTYCCEFDITYSYAIVSSIISFYIPLVIMVFVYSRVF 218

  Fly   300 CVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDM 364
                                                                   |...|:|:.:
Zfish   219 -------------------------------------------------------QEARKQLKKI 228

  Fly   365 MLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKR 429
                                                                             
Zfish   229 ----------------------------------------------------------------- 228

  Fly   430 ASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRS 494
                     ..|.|                       :.|:.....|.....::|.|     :||
Zfish   229 ---------NKTEG-----------------------RFHAQKSNSRNQDVANNHSE-----MRS 256

  Fly   495 HHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFIN 559
            ......|                               .||:|..:||.|::|.|..||||||:.
Zfish   257 TKKAKFY-------------------------------LKEHKALKTLGIIMGVFTLCWLPFFVL 290

  Fly   560 YLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC 610
            .:|    .:........:.|.|:|:.|||.||.||. .|.|||.||..:.|
Zfish   291 NVI----PKGSVDIWTFRILNWIGYANSAFNPLIYC-GSPDFRYAFKEILC 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	70/195 (36%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	7/24 (29%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	29/71 (41%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
adrb2a	NP_001096122.1	7tm_GPCRs	31..331	CDD:475119	111/495 (22%)
		TM helix 1	31..55	CDD:410628	8/23 (35%)
		TM helix 2	64..86	CDD:410628	12/21 (57%)
		TM helix 3	102..124	CDD:410628	12/21 (57%)
		TM helix 4	147..163	CDD:410628	4/15 (27%)
		TM helix 5	192..215	CDD:410628	9/22 (41%)
		TM helix 6	270..291	CDD:410628	11/20 (55%)
		TM helix 7	300..325	CDD:410628	10/25 (40%)