Protein Alignment TyrR and htr7a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_021328829.2
• Gene: htr7a / 562111
• ZFINID: ZDB-GENE-130530-666
• Length: 479
• Species: Danio rerio
• Alignment Length: 524
• Identity: 144/524 - (27%)
• Similarity: 219/524 - (41%)
• Gaps: 174/524 - (33%)

  Fly   111 VLSW---QGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPP 172
            :||:   :.:::..|.....::|:.||.||::::...::||..:|..::|||:|||.|.:.|||.
Zfish    96 ILSYGEVEKVLIGGVLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPF 160

  Fly   173 AVAVHLIGS-WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALI 236
            .....|||. |..|...|:::|::||:.|||||::||.||:||||.:||||||..::....:|.
Zfish   161 VSITDLIGGRWIFGKFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAK- 224

  Fly   237 MILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARI--- 298
            |:|.||||:.:||.||:.||.: ...|.|.|..:|:.||.|:|...:|:|||.||:.:|.||
Zfish   225 MVLSVWLLSASITLPPLFGWAQ-NVNDDRVCLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFRA 288

  Fly   299 SCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQD 363
            :.:.|::| .:|.       |.|....:||.:..|::
Zfish   289 AKLSAAKH-TITG-------FPRVEQEEVEEDEVEED---------------------------- 317

  Fly   364 MMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLK 428
                               ||.||...||                  :.|       :|....|:
Zfish   318 -------------------GGDGAEEPTG------------------VDC-------VTVAIKLQ 338

  Fly   429 RASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLR 493
            |.......:..:..|:|                              |..|.|.|
Zfish   339 REVEECARLPRILRGVG------------------------------RRCSDRRS---------- 363

  Fly   494 SHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFI 558
                                               |:..|:|.|...||.||||.|..||||||:
Zfish   364 -----------------------------------ISIFKREQKAAATLGIVVGAFTICWLPFFL 393

  Fly   559 NYLITPFLAEHQASQM---LAKALTWLGWFNSAINPFIYAFYSVDFRAAFWR-LTC------KRF 613
            .....||:...:.|.:   :.:.|.|||:.||.||||||||::.|.|..:.. |:|      :|.
Zfish   394 LSTARPFICGTECSCIPLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYRSLLSCRYRNINRRL 458

  Fly   614 FSAG 617
            .:||
Zfish   459 SAAG 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/189 (41%)
		TM helix 1	118..144	CDD:320189	6/25 (24%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	11/22 (50%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	35/74 (47%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	14/27 (52%)
htr7a	XP_021328829.2	None