Protein Alignment TyrR and adora2aa

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001034904.1
• Gene: adora2aa / 561701
• ZFINID: ZDB-GENE-080723-28
• Length: 442
• Species: Danio rerio
• Alignment Length: 525
• Identity: 108/525 - (20%)
• Similarity: 170/525 - (32%)
• Gaps: 240/525 - (45%)

  Fly   118 ILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSW 182
            :|||      :::|:||.||..|:.....|::|||.||:||||||:.||:..:|.::.:..  .:
Zfish    15 LLIA------LLSVLGNVLVCWAVGLNSNLQSITNFFVVSLAVADIAVGVLAIPFSIVIST--GF 71

  Fly   183 QLGWVLCDIWISLDVLLCT-ASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            ...:..| ::|:..||:.| :||.||.||::|||:|:..||.|:.....:| |..:|.|.|:|::
Zfish    72 CANFYGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIKIPLRYNSLVTGQR-ARGIIAICWVLSV 134

  Fly   247 AITCPPMLGWYE------------PGRRDLRECRYNQ---NEGYVIFSAMGSFFIPMAVMIYVYA 296
            .|...|||||::            ||   :.||.:.:   .:..|.|:......:|:.:|:.:|.
Zfish   135 IIGLTPMLGWHKARLQEGHNGTCPPG---MMECLFEEVVVMDYMVYFNFFACVLVPLLLMLAIYL 196

  Fly   297 RISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKEL 361
            ||  .:|:||
Zfish   197 RI--FMAARH------------------------------------------------------- 204

  Fly   362 QDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSS 426
                                                .|..:.|..:                |..
Zfish   205 ------------------------------------QLKCIESKAI----------------PCE 217

  Fly   427 LKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRER 491
            ||..||
Zfish   218 LKSRST----------------------------------------------------------- 223

  Fly   492 LRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPF 556
                                                    |:||....::|:|:||.|..||||.
Zfish   224 ----------------------------------------LQKEVHAAKSLAIIVGLFAVCWLPL 248

  Fly   557 FINYLITPFLAEHQASQMLAKALT-WLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKP 620
            .|....|.|..|.:....|...|. .|...||.:||||||:...:||..|.::.  |:...|::.
Zfish   249 HIINCFTLFCPECERPPALIMYLAIILSHANSVVNPFIYAYRIREFRHTFRKIV--RYHILGRRE 311

  Fly   621 QFPTN 625
            ....|
Zfish   312 PLSCN 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	65/201 (32%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	15/30 (50%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	5/24 (21%)
		7tm_GPCRs	<533..605	CDD:475119	28/72 (39%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	11/25 (44%)
adora2aa	NP_001034904.1	7tmA_Adenosine_R_A2A	8..298	CDD:320196	104/503 (21%)
		TM helix 1	9..35	CDD:320196	9/25 (36%)
		TM helix 2	42..69	CDD:320196	13/26 (50%)
		TM helix 3	78..108	CDD:320196	15/30 (50%)
		TM helix 4	122..140	CDD:320196	6/17 (35%)
		TM helix 5	172..202	CDD:320196	7/31 (23%)
		TM helix 6	225..255	CDD:320196	12/29 (41%)
		TM helix 7	266..291	CDD:320196	11/24 (46%)