Protein Alignment TyrR and htr1b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001122181.1
• Gene: htr1b / 561647
• ZFINID: ZDB-GENE-081022-141
• Length: 380
• Species: Danio rerio
• Alignment Length: 503
• Identity: 135/503 - (26%)
• Similarity: 195/503 - (38%)
• Gaps: 171/503 - (33%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :.|.:|.....:.|::.|..||..|..:|:|:|..|..:.||||.||||.:.|||..|...:...
Zfish    42 VTLSSVLGLITLATILSNAFVIATISQSRKLQTPANFLIASLAVTDLLVSVLVMPICVLYTVTRE 106

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |.||.|:||||:|.|:..||||||.||.|::|||.|:|..:.|::||...| |..|:...|::|:
Zfish   107 WTLGQVICDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYAKKRTQAR-AAGMVATAWIIAI 170

  Fly   247 AITCPPMLGWYEPGRRDLRECRYNQNE-GYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMT 310
            :|:.||.. |.:....:|..|..|.:. .|.|:|..|:|:||..::|.:|.||  .:.:|
Zfish   171 SISLPPFF-WRQVKAGELTTCSVNTDHIFYTIYSTFGAFYIPTLLLIALYGRI--YVEAR----- 227

  Fly   311 DISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAM 375
                     ||..          ::.....|:|...|...|.|..::|
Zfish   228 ---------KRIL----------KQSPKKPGKRLTSAHLSTNSPASVA----------------- 256

  Fly   376 GAGGAGGGGGGASSATGGTHC--QSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTIT 438
                          :|...||  |.|             |:.:|
Zfish   257 --------------STSPLHCGRQDL-------------CSDSG--------------------- 273

  Fly   439 TMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHH 503
                      ||          |...|::
Zfish   274 ----------SL----------GSDNQIR------------------------------------ 282

  Fly   504 QAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAE 568
                .|.|.|          .|..:..|..:|.|.|:||.|::|.:|.|||||||..|:.| |..
Zfish   283 ----VTVSDS----------LLEKKRISAARERKATKTLGIILGAYIVCWLPFFIYTLLIP-LCS 332

  Fly   569 HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL----TCKR 612
            ...|..|....||||:.||.|||.||...:.||:.||.::    .|:|
Zfish   333 SCFSPELFDFFTWLGYVNSLINPIIYTMSNDDFKKAFHKVISFRCCRR 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	73/186 (39%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/25 (36%)
		7tm_GPCRs	<533..605	CDD:475119	33/71 (46%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
htr1b	NP_001122181.1	7tm_GPCRs	39..369	CDD:475119	131/490 (27%)
		TM helix 1	44..68	CDD:320455	7/23 (30%)
		TM helix 2	77..99	CDD:320455	12/21 (57%)
		TM helix 3	115..137	CDD:320455	14/21 (67%)
		TM helix 4	160..176	CDD:320455	4/15 (27%)
		TM helix 5	197..220	CDD:320455	8/22 (36%)
		TM helix 6	304..326	CDD:320455	13/21 (62%)
		TM helix 7	337..362	CDD:320455	12/24 (50%)