Protein Alignment TyrR and adora2b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001034902.1
• Gene: adora2b / 560100
• ZFINID: ZDB-GENE-060511-1
• Length: 351
• Species: Danio rerio
• Alignment Length: 536
• Identity: 110/536 - (20%)
• Similarity: 174/536 - (32%)
• Gaps: 254/536 - (47%)

  Fly   118 ILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSW 182
            :.||:.....|:::.||.||..|:.....|:..||.|::||||||:|||...:|.|:.:. ||.|
Zfish     4 LYIAIELVIAVLSIAGNVLVCWAVAINSTLKNATNYFLVSLAVADILVGCLAIPFAITIS-IGLW 67

  Fly   183 QLGWVLCDIWISLDVLLCT-ASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            . .:..| ::::..||:.| :||.||.|:::||||||..||.|......|| |..:|.|:|:|:.
Zfish    68 S-DFYGC-LFLACFVLVLTQSSIFSLLAVAIDRYLAVKIPLRYRELVTGKR-AREIITILWILSF 129

  Fly   247 AITCPPMLGWYEPGRRDLR--------------------------------ECRYNQ--NEGYVI 277
            .|...|.:||   .|:||.                                ||.:.:  :..|::
Zfish   130 IIGLIPFVGW---NRKDLACSRNKSGSLQTSNSSDDDAAETETGFLQSCYLECFFEKVVDMSYMV 191

  Fly   278 -FSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVG 341
             |:..|....|:.:|:.:||:|                       :|.|
Zfish   192 YFNFFGCVLPPLLIMLGIYAKI-----------------------FTVA---------------- 217

  Fly   342 QRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGG 406
                            .|:|:.:.|    .|:.
Zfish   218 ----------------RKQLRQIEL----KCSV-------------------------------- 230

  Fly   407 VGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSL 471
                                                                             
Zfish   231 ----------------------------------------------------------------- 230

  Fly   472 SQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKEN 536
                       |:||        :.||       |:                        |::|.
Zfish   231 -----------SNGE--------NQHH-------GL------------------------LQREI 245

  Fly   537 KTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDF 601
            :..::|||:||.|..||||..|...:|.|.:|.:....:......|...|||:||.|||:...:|
Zfish   246 RAAKSLSIIVGLFALCWLPVHILNCLTLFYSELKKPSFIMNIAIILSHANSAVNPIIYAYRIREF 310

  Fly   602 RAAFWR-----LTCKR 612
            |..|.:     :.|:|
Zfish   311 RVTFRKILNRHILCQR 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	68/221 (31%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	14/25 (56%)
		TM helix 3	189..219	CDD:320189	14/30 (47%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	6/25 (24%)
		7tm_GPCRs	<533..605	CDD:475119	26/71 (37%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
adora2b	NP_001034902.1	7tm_GPCRs	3..314	CDD:475119	107/522 (20%)
		TM helix 1	5..29	CDD:410628	8/23 (35%)
		TM helix 2	38..60	CDD:410628	12/21 (57%)
		TM helix 3	74..96	CDD:410628	8/21 (38%)
		TM helix 4	119..135	CDD:410628	5/15 (33%)
		TM helix 5	188..211	CDD:410628	5/22 (23%)
		TM helix 6	248..270	CDD:410628	11/21 (52%)
		TM helix 7	282..307	CDD:410628	9/24 (38%)