Protein Alignment TyrR and si:dkey-247m21.3

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_017208337.2
• Gene: si:dkey-247m21.3 / 559089
• ZFINID: ZDB-GENE-091204-249
• Length: 390
• Species: Danio rerio
• Alignment Length: 535
• Identity: 128/535 - (23%)
• Similarity: 188/535 - (35%)
• Gaps: 222/535 - (41%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLR-TITNCFVMSLAVADLLVGIFVMPPAVAVHLIG 180
            |.|..|..|.|::|.:||.||::|:...|:|| ..||.|::|||.|||||.:.|||.|......|
Zfish    23 ITLSIVLVTIIIMTALGNLLVMVALCKDRQLRKKKTNFFIVSLAFADLLVALVVMPLAAIELTTG 87

  Fly   181 SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAV-TRPLTYSRKRRSKRLALIMILIVWLL 244
            .|..|...|.:..||||||.|||||.||.|::|||.|: .:||.|:.|....|::| |::..|::
Zfish    88 KWNYGETFCLVRTSLDVLLTTASILHLCCIALDRYYAICCQPLVYNNKMTPVRVSL-MLVGCWVI 151

  Fly   245 ALAIT-CPPMLGWYEPG------RRDLRE-----CRYNQNEGYVIFSAMGSFFIPMAVMIYVYAR 297
            ...|: .|.|..|...|      :|.|..     |.:..|:.|.:..:..:|::|:.:|:..|.|
Zfish   152 PFFISFLPIMQSWNTIGIESFIEQRKLNSSRNSTCVFMVNQPYALVCSAVAFYVPLVLMVLAYQR 216

  Fly   298 ISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQ 362
            |                       |..|
Zfish   217 I-----------------------YVTA------------------------------------- 221

  Fly   363 DMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSL 427
                                                            ||.|:       |..||
Zfish   222 ------------------------------------------------MGHAR-------RIGSL 231

  Fly   428 KRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERL 492
                                                                             
Zfish   232 ----------------------------------------------------------------- 231

  Fly   493 RSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFF 557
                      |:||...|||..|...:.:|:        :|.|.|..:||::::|.|..||.|||
Zfish   232 ----------HRAGSAPTSTYPNNDQHGSSR--------IKNETKAAKTLAVIMGCFCLCWAPFF 278

  Fly   558 INYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC---KRF-----F 614
            :..::.||: .:.....:..|..|||:.||.:|||:|||.:..||.||..:.|   :|:     |
Zfish   279 VTNVVDPFI-NYSVPWQMWTAWLWLGYINSGLNPFLYAFLNRAFRRAFLMILCCGDERYARQGGF 342

  Fly   615 SAGQKPQFPTNTMSI 629
            |..::.....|..||
Zfish   343 SPSRQCSESVNGTSI 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	74/199 (37%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	15/25 (60%)
		TM helix 3	189..219	CDD:320189	19/30 (63%)
		TM helix 4	232..255	CDD:320189	7/23 (30%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	28/71 (39%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
si:dkey-247m21.3	XP_017208337.2	7tmA_5-HT4	23..325	CDD:320184	119/501 (24%)
		TM helix 1	24..50	CDD:320184	10/25 (40%)
		TM helix 2	58..84	CDD:320184	15/25 (60%)
		TM helix 3	96..126	CDD:320184	19/29 (66%)
		TM helix 4	139..162	CDD:320184	6/23 (26%)
		TM helix 5	191..220	CDD:320184	9/51 (18%)
		TM helix 6	254..284	CDD:320184	12/29 (41%)
		TM helix 7	293..318	CDD:320184	12/24 (50%)