Protein Alignment TyrR and adrb1

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001122161.1
• Gene: adrb1 / 557194
• ZFINID: ZDB-GENE-081022-145
• Length: 390
• Species: Danio rerio
• Alignment Length: 560
• Identity: 140/560 - (25%)
• Similarity: 200/560 - (35%)
• Gaps: 244/560 - (43%)

  Fly    64 VGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIV 128
            :|.|.||                     .||.|:|..|.     .||.:|.|.::.:.:....||
Zfish     1 MGDGLPS---------------------VNYSNDSKRAT-----VDLNVSEQWLVGMGILMGLIV 39

  Fly   129 -VTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIW 192
             |.|:||.|||:||...:||:|:||.|::|||.|||::|:.|:|...|:.:.|:|..|...|:.|
Zfish    40 FVIVVGNILVIVAIARNQRLQTLTNVFIVSLACADLIMGLLVVPFGAALEVRGAWMYGSFFCEFW 104

  Fly   193 ISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPML-GW 256
            ||||||..||||.:||.|::|||:|:..|..| :...:|..|.:::..||.::..::.||:| .|
Zfish   105 ISLDVLCVTASIETLCVIAIDRYIAIISPFRY-QSLLTKARAKVVVCAVWAISALVSFPPILMHW 168

  Fly   257 YEPGRRDLRE---------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDI 312
                .:|..|         |.:..|..|.|.|::.||:||:.|||:||||:
Zfish   169 ----SQDSEETSCYENPECCDFVTNRAYAISSSIISFYIPLIVMIFVYARV-------------- 215

  Fly   313 SVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGA 377
                                           .|:|..:               |:..:.|..
Zfish   216 -------------------------------YREAKQQ---------------LNKINKCEG--- 231

  Fly   378 GGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTS 442
                                                                             
Zfish   232 ----------------------------------------------------------------- 231

  Fly   443 GMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGV 507
                                                .|.::||
Zfish   232 ------------------------------------RFYNNHG---------------------- 238

  Fly   508 TTTSTSGNTSANTNSKSLSNRITSL--KKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQ 570
                        ||.|....|.|.:  .||.|..:||.|::|.|..|||||||..::..|.|: .
Zfish   239 ------------TNCKPTRKRTTKILALKEQKALKTLGIIMGTFTLCWLPFFIVNVVRVFCAQ-V 290

  Fly   571 ASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC 610
            ..:.|...|.|||:.|||.||.||. .|.|||.||.||.|
Zfish   291 VDKELFVFLNWLGYVNSAFNPIIYC-RSPDFRKAFKRLLC 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/196 (39%)
		TM helix 1	118..144	CDD:320189	11/26 (42%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	6/23 (26%)
		TM helix 5	272..297	CDD:320189	13/24 (54%)
		7tm_GPCRs	<533..605	CDD:475119	33/71 (46%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
adrb1	NP_001122161.1	7tm_GPCRs	30..324	CDD:475119	122/498 (24%)
		TM helix 1	31..55	CDD:320624	11/23 (48%)
		TM helix 2	64..86	CDD:320624	11/21 (52%)
		TM helix 3	102..124	CDD:320624	14/21 (67%)
		TM helix 4	147..163	CDD:320624	2/15 (13%)
		TM helix 5	190..213	CDD:320624	11/22 (50%)
		TM helix 6	260..282	CDD:320624	12/21 (57%)
		TM helix 7	293..318	CDD:320624	12/25 (48%)