Protein Alignment TyrR and drd4b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 498
• Identity: 134/498 - (26%)
• Similarity: 203/498 - (40%)
• Gaps: 156/498 - (31%)

  Fly   116 GIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIG 180
            ||:|       |:|.:.||.||.|::...:.|:|.||.|::|||||||::.:.|:|..|.....|
Zfish    24 GILL-------IIVIICGNVLVCLSVYKEKALKTTTNYFIVSLAVADLMLAVLVLPLFVYAEFQG 81

  Fly   181 S-WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLL 244
            . |.|...:||..:::||:||||||.:||||||||::||:.||.|:||....| .:|::...|||
Zfish    82 GVWSLNVSVCDGLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRKHVDYR-QIILLSATWLL 145

  Fly   245 ALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNM 309
            |||:..|.:.|.....:||..||:...| .||::|::.|||||..:|:.:|..:
Zfish   146 ALAVASPVIFGINNVPQRDPSECKLEDN-NYVVYSSVCSFFIPCPIMLMLYFGM----------- 198

  Fly   310 TDISVHN-KKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCA 373
                .|. :|::....|.:.|.:              ||          .:.||
Zfish   199 ----FHGLRKWEETRKAKLRNSI--------------QA----------CRSLQ----------- 224

  Fly   374 AMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKR------AST 432
                                 |.....|||..|               ..|:||.|      |.:
Zfish   225 ---------------------HAAVAAALPPLG---------------ALPASLPRVIERDLAQS 253

  Fly   433 ASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHH 497
            :...:...|..:.|          ..|..:...:||.:.|.        ..:|::.:.:.|
Zfish   254 SLEELDDFTQPVCP----------FPPEYKNSTIQTVAYSD--------IQYGQKTQRKKR---- 296

  Fly   498 HPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLI 562
                                |..|.           :|.|..:.|.:|||.|:.||.|||:.:..
Zfish   297 --------------------AKING-----------RERKAMRVLPVVVGVFLFCWTPFFVVHTT 330

  Fly   563 TPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            .........|..|...:||||:.|||:||.||..::.:||..|
Zfish   331 RALCESCHISSDLMSTVTWLGYVNSALNPIIYTVFNTEFRKFF 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	76/186 (41%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	133/496 (27%)
		TM helix 1	20..45	CDD:320434	10/27 (37%)
		TM helix 2	52..78	CDD:320434	13/25 (52%)
		TM helix 3	91..121	CDD:320434	19/29 (66%)
		TM helix 4	133..156	CDD:320434	9/23 (39%)
		TM helix 5	172..201	CDD:320434	11/44 (25%)
		TM helix 6	301..331	CDD:320434	12/40 (30%)
		TM helix 7	341..366	CDD:320434	12/24 (50%)