Protein Alignment TyrR and drd4a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001012634.2
• Gene: drd4a / 503564
• ZFINID: ZDB-GENE-070112-996
• Length: 380
• Species: Danio rerio
• Alignment Length: 496
• Identity: 135/496 - (27%)
• Similarity: 201/496 - (40%)
• Gaps: 159/496 - (32%)

  Fly   116 GIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAV-AVHLI 179
            ||:|       |::.:.||.||.|::.|.:.|:|.||.|::||||||||:.:.|:|..| |....
Zfish    27 GILL-------IIIIICGNVLVCLSVYTEKALKTTTNYFIVSLAVADLLLAVLVLPLFVYAEFQD 84

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLL 244
            |.|.|...:||..:::||:||||||.:|||||:||::||:.||.|:||...:| .::::...|:|
Zfish    85 GVWSLNMTVCDGLMTMDVMLCTASIFNLCAISIDRFIAVSIPLNYNRKHVDQR-QIVLLSATWIL 148

  Fly   245 ALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNM 309
            |||:..|.|.|......||..||:...| .|||:|::.|||:|..:|:.:|    |.:.....|.
Zfish   149 ALAVASPVMFGINNVPNRDHSECKLEDN-NYVIYSSVCSFFVPCPIMLLLY----CGMFRGLRNW 208

  Fly   310 TDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAA 374
                                            :..|:|..|  ||....::||:...|
Zfish   209 --------------------------------EEARKAKLR--SNMEACRKLQEAAAS------- 232

  Fly   375 MGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITT 439
                                 .|.|..||
Zfish   233 ---------------------LQPLSGLP------------------------------------ 240

  Fly   440 MTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERD--RERLRSHHHHPHYH 502
                               ||            .||..        |:|  .|.| ...|:|...
Zfish   241 -------------------PP------------LPPVI--------EKDITLEEL-DQDHYPDPD 265

  Fly   503 HQAGVTTTSTSG---NTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITP 564
            ....|:..:..|   |...|.|.:....:|..  :|.|..:.|.:|||.|:.||.|||:.:.:..
Zfish   266 SPDPVSMLAYPGGGYNQDQNQNRQRKRAKING--RERKAMRVLPVVVGAFLFCWTPFFVVHTMRA 328

  Fly   565 FLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF 605
            ...:.:....:...:||||:.||||||.||..::.:||..|
Zfish   329 LCEDCEIPGSVTSIVTWLGYVNSAINPIIYTVFNTEFRKFF 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/186 (41%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	15/26 (58%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	26/71 (37%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
drd4a	NP_001012634.2	7tmA_D4_dopamine_R	36..369	CDD:320434	130/478 (27%)
		TM helix 2	55..81	CDD:320434	14/25 (56%)
		TM helix 3	94..124	CDD:320434	18/29 (62%)
		TM helix 4	136..159	CDD:320434	8/23 (35%)
		TM helix 5	175..204	CDD:320434	12/33 (36%)
		TM helix 6	297..327	CDD:320434	12/31 (39%)
		TM helix 7	337..362	CDD:320434	12/24 (50%)