Protein Alignment TyrR and AdoR

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 112/495 - (22%)
• Similarity: 169/495 - (34%)
• Gaps: 194/495 - (39%)

  Fly   122 VFATFI-VVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLG 185
            ||...: :|::|||.|||:.....|:||..||.:::|||:||||||...:|.|:    :.|..|.
  Fly    46 VFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAI----LASMGLP 106

  Fly   186 WVL--CDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAI 248
            ..|  |...:||.|:|||.||..|.|:|||||.|:..|:.|||..|: |.|:.:|.:.|:....:
  Fly   107 RNLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRT-RTAIFIISMCWVAGTIV 170

  Fly   249 TCPPMLGWYEPGRRDLRECRYNQ--NEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTD 311
            ...|:.||:.....: :||.:.:  :..|::|....:...|..:|:..|..|..||.
  Fly   171 GFLPLFGWHADVNHN-QECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVII-------- 226

  Fly   312 ISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMG 376
                 |:.::....:..::||
  Fly   227 -----KQVRQIVTMNPASDLS-------------------------------------------- 242

  Fly   377 AGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMT 441
                                                               :|:|.|...:||
  Fly   243 ---------------------------------------------------RRSSAAVVQVTT-- 254

  Fly   442 SGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAG 506
                ||..           |.||
  Fly   255 ----PGRG-----------GHTG------------------------------------------ 262

  Fly   507 VTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQA 571
             |.....|               .:.|::.|.||.|||:|..|:.||:|.:....|..|..:...
  Fly   263 -TMLRVLG---------------AARKRDVKATQNLSIIVLFFMICWIPLYTINCIKAFCPDCYV 311

  Fly   572 SQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCK 611
            ...|......|...|||:||.:||::..|||||...|..|
  Fly   312 HPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLK 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	67/186 (36%)
		TM helix 1	118..144	CDD:320189	9/22 (41%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	5/22 (23%)
		TM helix 5	272..297	CDD:320189	5/24 (21%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	109/487 (22%)
		TM helix 1	43..69	CDD:341316	9/22 (41%)
		TM helix 2	76..103	CDD:341316	13/30 (43%)
		TM helix 3	112..142	CDD:341316	17/29 (59%)
		TM helix 4	156..174	CDD:341316	3/17 (18%)
		TM helix 5	196..225	CDD:341316	6/28 (21%)
		TM helix 6	273..303	CDD:341316	12/29 (41%)
		TM helix 7	313..338	CDD:341316	9/24 (38%)