Protein Alignment TyrR and Taar7f

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001010839.1
• Gene: Taar7f / 435207
• MGIID: 3527447
• Length: 358
• Species: Mus musculus
• Alignment Length: 501
• Identity: 113/501 - (22%)
• Similarity: 159/501 - (31%)
• Gaps: 216/501 - (43%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :||.|||....|:.|.||.||:.:||..|:|.:..|..|.|||.||.|||:.|||.::...:.|.
Mouse    48 LILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGVMVMPFSMVRSVEGC 112

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |..|...|.:....||..|..|:..||.||||||:||:.||.|. .|.:..::...|...|||::
Mouse   113 WYFGDSYCKLHTCFDVSFCYCSLFHLCFISVDRYIAVSDPLAYP-TRFTASVSGKCITFSWLLSI 176

  Fly   247 AITCPPM-LGWYEPGRRDLRE-------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIA 303
            :.....: .|..|.|..||..       |:...|:.:| |.....|.||..|||.||::|..:..
Mouse   177 SYGFSLIYTGASEAGLEDLVSSLTCVGGCQIAVNQTWV-FINFSVFLIPTLVMITVYSKIFLIAK 240

  Fly   304 SRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSD 368
            .:..|:       :|..:.||
Mouse   241 QQAQNI-------EKMSKQTA-------------------------------------------- 254

  Fly   369 SDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTA 433
                                                                        ||
Mouse   255 ------------------------------------------------------------RA--- 256

  Fly   434 STTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHH 498
                                                                             
Mouse   257 ----------------------------------------------------------------- 256

  Fly   499 PHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLIT 563
                                   |.|..:|:.  |:|.|..:||.|.|..|:..|||:||:..|.
Mouse   257 -----------------------SDSYKDRVA--KRERKAAKTLGIAVAAFLLSWLPYFIDSFID 296

  Fly   564 PFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLT 609
            .||. ......:.:.|.|:.::|||:||.||||:...||.|. :||
Mouse   297 AFLG-FITPTYVYEILVWIVYYNSAMNPLIYAFFYPWFRKAI-KLT 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	72/193 (37%)
		TM helix 1	118..144	CDD:320189	13/25 (52%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	14/29 (48%)
		TM helix 4	232..255	CDD:320189	4/23 (17%)
		TM helix 5	272..297	CDD:320189	11/24 (46%)
		7tm_GPCRs	<533..605	CDD:475119	29/71 (41%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
Taar7f	NP_001010839.1	7tm_GPCRs	49..337	CDD:475119	110/494 (22%)
		TM helix 1	50..74	CDD:410628	11/23 (48%)
		TM helix 2	83..105	CDD:410628	13/21 (62%)
		TM helix 3	121..143	CDD:410628	7/21 (33%)
		TM helix 4	166..182	CDD:410628	4/15 (27%)
		TM helix 5	210..233	CDD:410628	10/23 (43%)
		TM helix 6	272..294	CDD:410628	10/21 (48%)
		TM helix 7	305..330	CDD:410628	11/24 (46%)