Protein Alignment TyrR and Dop1R2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 605
• Identity: 183/605 - (30%)
• Similarity: 250/605 - (41%)
• Gaps: 206/605 - (34%)

  Fly    40 GLPENISIVYE---DAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAA 101
            |||.:..:|..   .|.:.|....:...|||                |.|.|....:.:.|:
  Fly    58 GLPTSTELVLNATTSATSATLSPAMVATGGG----------------GTTTPEPDLSEFLEA--- 103

  Fly   102 AEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVG 166
                      |....:.|:|....|...||.||:|||||::..|.|.|.||.|:.||||||.|||
  Fly   104 ----------LPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVG 158

  Fly   167 IFVMP-PAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRS 230
            :.||| .|:...|..:|..|...||||.|||||..|||||:||.||:|||.|:|.|.:|..:...
  Fly   159 LVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTV 223

  Fly   231 KRLALIMILIVWLLALAITCPPMLGW--YEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIY 293
            || |..:|..||:.:.||:.|.::.|  ...|.....:|.:.::.||::||:..||::|:.||::
  Fly   224 KR-AAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVF 287

  Fly   294 VYARISCVIASRHDNMTDISVHNKKFKRYTAADVEN---ELSEQEQHSSVGQRQ------RQATS 349
            .|.||                       |.||.::.   ::..::...:.|:.|      |..|:
  Fly   288 TYCRI-----------------------YRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTT 329

  Fly   350 RTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCA 414
            |...||.                    :||.||||||                  ||.|||:
  Fly   330 RDQQNQV--------------------SGGGGGGGGG------------------GGGGGSL--- 353

  Fly   415 KNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHS 479
                                                                          :||
  Fly   354 --------------------------------------------------------------SHS 356

  Fly   480 FRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGN-----TSANTNSK-----------SLSNR 528
            ..|||          ||||.|    .|.|||||...     .||..|:.           |||.:
  Fly   357 HSHSH----------HHHHNH----GGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRK 407

  Fly   529 ITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPF---LAEHQASQMLAKALTWLGWFNSAIN 590
            :....||.|..:||.||:|.||.||||||:..|::.|   ..||:  ::::..:|||||.||.:|
  Fly   408 LAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHE--EIVSAIVTWLGWINSCMN 470

  Fly   591 PFIYAFYSVDFRAAFWRLTC 610
            |.|||.:|.|||.||.||.|
  Fly   471 PVIYACWSRDFRRAFVRLLC 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	83/188 (44%)
		TM helix 1	118..144	CDD:320189	12/25 (48%)
		TM helix 2	151..177	CDD:320189	16/26 (62%)
		TM helix 3	189..219	CDD:320189	22/29 (76%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	36/74 (49%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	161/505 (32%)
		TM helix 2	143..169	CDD:320195	16/25 (64%)
		TM helix 3	182..212	CDD:320195	22/29 (76%)
		TM helix 4	224..246	CDD:320195	9/22 (41%)
		TM helix 5	266..295	CDD:320195	13/51 (25%)
		TM helix 6	297..442	CDD:320195	59/261 (23%)
		TM helix 7	453..478	CDD:320195	12/24 (50%)