Protein Alignment TyrR and CG12290

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_651470.1
• Gene: CG12290 / 43182
• FlyBaseID: FBgn0039419
• Length: 798
• Species: Drosophila melanogaster
• Alignment Length: 690
• Identity: 127/690 - (18%)
• Similarity: 222/690 - (32%)
• Gaps: 261/690 - (37%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIG- 180
            :||..:..:|::     |.|.:.|...|..|||..|.|.::| :|..|:|..::.|.:.:.|.|
  Fly     6 LILALLLVSFLI-----NLLALCAFWITPGLRTTANRFTINL-LAINLIGCCILAPTLFLGLPGK 64

  Fly   181 ---------------------------SWQL---------------------------------- 184
                                       :.||
  Fly    65 SAEASTSNAETLEFFSKPGNHQVILRRNGQLVEQDGVVVRRNISENGDTVETFFKCNATYCRELT 129

  Fly   185 -------GWVLCD---------------------------IWISLDVLLCTASILSLCAISV--D 213
                   |:|:.:                           .| |:|:   ||::.:|..:.|  |
  Fly   130 IDERGDGGFVITETETHEENLSAFESLPTEAPILPPVQLRCW-SIDM---TAALGALAVLLVVGD 190

  Fly   214 RYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL---AITCPPMLGWYEPG----RRDLRECRYNQ 271
            .:.|||.||.| ..|.|.....|.|.:.|::.:   |::...:|.:....    :|.|....:|.
  Fly   191 TWCAVTDPLRY-HSRISGVKTWIFIALTWVVGILFGALSAFRVLDFEADALFSRQRRLAVTYFNI 254

  Fly   272 NEGYVIFSAM--GSFFI-----PMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVEN 329
            :....||..:  ..:||     |...:..:|.||          .::...:..:.::    :..:
  Fly   255 SSTNSIFGVVYASVYFIVIILLPFGFVCGMYWRI----------FSEARGNGLRMRQ----NGSS 305

  Fly   330 ELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGT 394
            .|.:...:.:.||:..||..  |||..               |....:..:....||.||.
  Fly   306 PLLQSALNLTAGQQAAQANQ--FSNSL---------------CVHRHSISSASSHGGNSSL---- 349

  Fly   395 HCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMT------SGMGPGSSLLDA 453
                       |:||............:.||.|:|.|.|...:.|::      :..|.|..|:..
  Fly   350 -----------GLGGLQMQIDQRQQPRSSPSCLRRDSAAKVLLPTISDDGGSDAESGAGVQLMPV 403

  Fly   454 Q-----------------------------------WQSQPPGQTGQV----QTHSLSQPPRTHS 479
            |                                   ..||...:|.::    |.||   .|..|.
  Fly   404 QEHSLSDRNQNIMLTLQTASGEIKRNYSARQLPLLGTSSQDLRETNRLQGIRQVHS---SPNLHK 465

  Fly   480 FRH----------------SHGERDRE-------RLRSHH----HHPHY----HHQAG--VTTTS 511
            :..                .|.:|.::       :.:.||    ||||:    |.|.|  :...:
  Fly   466 YTELRQDSLSEECGSPHLLGHAQRQQQQQLHLQHQQQQHHHHQQHHPHFSSPRHQQHGHALQIPA 530

  Fly   512 TSGNTSANTNSKSLSNRITS------LKKENKTTQTLSIVVGGFIACWLPFFINYLITPFL--AE 568
            ...:..|.:...||.:|:::      .::|::..:...:||..|:..:|||.:..|:...|  |.
  Fly   531 IHASPKALSYMSSLRHRLSNASSLFKYREESRAARISILVVVMFVVSYLPFGLLVLLQSRLSAAN 595

  Fly   569 HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            ...|..||..:..|...:|   |||:|:.:...|....||
  Fly   596 FGGSSQLAIFMILLANLSS---PFIFAYRNKRVRRGVKRL 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	55/297 (19%)
		TM helix 1	118..144	CDD:320189	6/25 (24%)
		TM helix 2	151..177	CDD:320189	7/25 (28%)
		TM helix 3	189..219	CDD:320189	9/58 (16%)
		TM helix 4	232..255	CDD:320189	4/25 (16%)
		TM helix 5	272..297	CDD:320189	6/31 (19%)
		7tm_GPCRs	<533..605	CDD:475119	20/73 (27%)
		TM helix 6	539..561	CDD:320189	6/21 (29%)
		TM helix 7	573..598	CDD:320189	8/24 (33%)
CG12290	NP_651470.1	7tm_classA_rhodopsin-like	<192..>312	CDD:410626	25/134 (19%)
		TM helix 4	209..228	CDD:410626	4/18 (22%)
		TM helix 5	262..287	CDD:410626	4/24 (17%)
		7tm_classA_rhodopsin-like	<544..622	CDD:410626	21/80 (26%)
		TM helix 6	558..588	CDD:410626	8/29 (28%)
		TM helix 7	600..622	CDD:410626	8/24 (33%)