Protein Alignment TyrR and TyrRII

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 244/596 - (40%)
• Similarity: 337/596 - (56%)
• Gaps: 61/596 - (10%)

  Fly    64 VGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWA----HFYDLVLSWQGIILIAVFA 124
            |..|..:..:||..:..|...|...|..     ..|.|.:..    :.|.:.::|...:.:|||.
  Fly    23 VASGNSNSSDGTLLLIQTSAAPGGDVMA-----TGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFL 82

  Fly   125 TFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLC 189
            ..|:|||:||||||||:||||||||:||||||:||:.|.|||..||||:|.:::.|:|:.||:||
  Fly    83 VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILC 147

  Fly   190 DIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPML 254
            |||||||:|||:.|||||||||:|||||||:|||||:|||||||||:|||:||:.||:|||||.|
  Fly   148 DIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYL 212

  Fly   255 GWYEPGRR--DLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNK 317
            ||||.||.  :..:||||||:|||:||||||||||:.||:|||.:|..|:.||...:.. ..:::
  Fly   213 GWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVR-DAYSE 276

  Fly   318 KFKRYTAADVENELSEQEQHSSVGQR---QRQATSR---------TFSNQTIAKELQ-DMMLSDS 369
            :...|. .|.:|.:||.|.:.....:   .|::..|         :.:....||..| .:..|..
  Fly   277 RTADYD-VDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKC 340

  Fly   370 DNC-AAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTA 433
            ..| :|.|..|||.|.|.........|..:...|                .|::|.|||...|..
  Fly   341 SKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYEL----------------VEVSRLSSLIHCSAI 389

  Fly   434 S-----TTITTMTSGM---GPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRE 490
            |     ..:.:..|||   |..:|..|..........|....|::::..........:..::.::
  Fly   390 SCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQ 454

  Fly   491 RLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLP 555
            |....|||||.||.      .:.|..|.:.:...:..|:::.|:::||.:||:||:||.||||||
  Fly   455 RSSFDHHHPHAHHH------GSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLP 513

  Fly   556 FFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKP 620
            ||:.||:.|||......:.|....||:||.|.||||||||||:.|||.|||||||:...    |.
  Fly   514 FFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPIC----KQ 574

  Fly   621 QFPTNTMSIRR 631
            :.|.|.:::.|
  Fly   575 KRPPNHLAMFR 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	131/187 (70%)
		TM helix 1	118..144	CDD:320189	16/25 (64%)
		TM helix 2	151..177	CDD:320189	17/25 (68%)
		TM helix 3	189..219	CDD:320189	25/29 (86%)
		TM helix 4	232..255	CDD:320189	16/22 (73%)
		TM helix 5	272..297	CDD:320189	19/24 (79%)
		7tm_GPCRs	<533..605	CDD:475119	41/71 (58%)
		TM helix 6	539..561	CDD:320189	14/21 (67%)
		TM helix 7	573..598	CDD:320189	15/24 (63%)
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	133/191 (70%)
		TM helix 1	78..101	CDD:410628	15/22 (68%)
		TM helix 2	110..132	CDD:410628	15/21 (71%)
		TM helix 3	148..170	CDD:410628	18/21 (86%)
		TM helix 4	194..210	CDD:410628	10/15 (67%)
		TM helix 5	233..256	CDD:410628	17/22 (77%)
		7tm_GPCRs	<491..563	CDD:475119	41/71 (58%)
		TM helix 6	497..519	CDD:320098	14/21 (67%)
		TM helix 7	531..556	CDD:320098	15/24 (63%)