Protein Alignment TyrR and 5-HT2B

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 894
• Identity: 186/894 - (20%)
• Similarity: 276/894 - (30%)
• Gaps: 390/894 - (43%)

  Fly    95 YNESAAAAEWAHFYDLVLS----WQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFV 155
            :|.:..|...|.|.|:...    |..:.|:.|..     |..||.||.|||...|||:.:||.|:
  Fly    53 WNATGNATISATFEDVPFDANNYWALLALVLVLG-----TAAGNILVCLAIAWERRLQNVTNYFL 112

  Fly   156 MSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTR 220
            ||||:.||:|.:.|||..:...:.|.:.||...|..||.||||.|||||:.||.|||||||::..
  Fly   113 MSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRY 177

  Fly   221 PLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYV--------- 276
            |:.:.|.:..:|:.| .|:.||||::|::.|..|             .|::|...|
  Fly   178 PMRFGRNKTRRRVTL-KIVFVWLLSIAMSLPLSL-------------MYSKNHASVLVNGTCQIP 228

  Fly   277 --IFSAMGS---FFIPMAVMIYVYARISCVIASRHDNM--------------------------- 309
              ::..:||   |:||:.||:..|.....::|.:..|:
  Fly   229 DPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERR 293

  Fly   310 ---------------------------TDIS------------------------VH-------- 315
                                       ||:|                        :|
  Fly   294 CTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLK 358

  Fly   316 ------------------NKKF--------------KRYTAADVENELSEQEQHSSVGQRQRQAT 348
                              ..:|              :||.|...::.....:||.: |...:||:
  Fly   359 LSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPA-GVYHQQAS 422

  Fly   349 SR--------TFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGG---------------GGASSA 390
            .:        ..|..|:..|.:    |..::.|:...||....|               ..||||
  Fly   423 PKGRHGTTVLGLSTTTLGIERE----STRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSA 483

  Fly   391 ----------------------------------------------------------------- 390
                                                                             
  Fly   484 VPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQ 548

  Fly   391 ------------------------TGGTHCQSLLALPS------GGVGGSMGCAKNGCYELTRPS 425
                                    .|..|....|.|||      .|......|.|:.  |:...|
  Fly   549 QTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSA--EVKIIS 611

  Fly   426 SLKRASTASTTITTMTSGM-----------------------GP--------------------G 447
            |..|.:|.:|.:::..|.|                       ||                    |
  Fly   612 SAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQG 676

  Fly   448 SSLL---DAQWQSQPPG------------------------------QTGQVQTHSLSQPPRTHS 479
            |||.   |.......||                              ..|.|:|..|..|.:|.:
  Fly   677 SSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTAT 741

  Fly   480 FRHSHGERDRERLRSHHHHPHYH---HQAGVTTTSTSG----------------NTSANTNSKSL 525
            ..:|.....|......|.:.:|.   ...|.|.|:||.                |:|..:.:.|.
  Fly   742 TSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSR 806

  Fly   526 SNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLA--EHQASQMLAKALTWLGWFNSA 588
            ..||  ::.|.|.|:.|.:|...|:..|.|||:..|:....|  |.:.|..:...:||||:.:|.
  Fly   807 HGRI--IRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSM 869

  Fly   589 INPFIYAFYSVDFRAAFWRLTCKRFFSAG-------QKPQFP----TNT 626
            :||..|..::..||.||.::...|:.|..       |.|..|    |||
  Fly   870 VNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSRXQTPVKPGKLKTNT 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	58/121 (48%)
		7tm_1	133..>298	CDD:278431	70/178 (39%)
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	71/185 (38%)
		7tm_4	90..>238	CDD:304433	63/161 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840