DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and 5-HT2A

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_730859.1 Gene:5-HT2A / 40575 FlyBaseID:FBgn0087012 Length:930 Species:Drosophila melanogaster


Alignment Length:681 Identity:185/681 - (27%)
Similarity:263/681 - (38%) Gaps:203/681 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 PNGTDAVALTEPGPTAPVTTFNYYNESAAAAEW----AHFYDLVLSWQGIILIAVFATFIVVTVI 132
            ||      ||....|:..:|.:...|.|....:    .|.||.      :.|..||  ||....:
  Fly   251 PN------LTALNTTSTASTADMATEFAVTKSFLDYSPHGYDF------LFLFVVF--FIFAGGL 301

  Fly   133 GNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDV 197
            ||.||.||:...|:|:.:||.|:.|||:|||||.:||||.......:|.|.||:..|:|:::.||
  Fly   302 GNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFVMPMGAIPAFLGYWPLGFTWCNIYVTCDV 366

  Fly   198 LLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCP-PMLGWY---- 257
            |.|::|||.:|.||:.||:.:..||. ||.|.:|||..|.|.|||::|:.::.. .:||..    
  Fly   367 LACSSSILHMCFISLGRYMGIRNPLG-SRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKN 430

  Fly   258 ---EPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKF 319
               ||     ..|..| |..:.:|.::.:|:|||.:|:..||             ..|.:..|| 
  Fly   431 IMPEP-----NICVIN-NRAFFVFGSLVAFYIPMLMMVTTYA-------------LTIPLLRKK- 475

  Fly   320 KRYTAADVENEL--------SEQEQHS------------------SVGQRQRQ-----------A 347
            .|:.|...|:||        :.:.|||                  |:|...|.           |
  Fly   476 ARFAAEHPESELFRRLGGRFTLRPQHSQQQLQMFSSFSGSNNKFLSMGDGNRNFNTEGEMEEGGA 540

  Fly   348 TSRTFSNQTIAKELQDMMLSDSDNCAAM-------GAGGAGGGG-------------GGA----- 387
            .||....:...:.|.....:.|.:...:       |..||.|.|             .||     
  Fly   541 PSRRSGVEPAERPLMQQRTASSRSMGTVSFRNVVNGTSGAAGSGRRTTGTAHSSFRFSGAGIFRH 605

  Fly   388 SSATGGTHCQSL-----------------------------LALPS------------------- 404
            ||::..:.|.|.                             |..||                   
  Fly   606 SSSSPASSCHSTSTSRSSSFWRKHGGYPNLMDRLAIHLRLSLVPPSSHPNRRASVRVTISQPQLG 670

  Fly   405 -----GGVGG------SMGCAKNGCYELTRPSSLKRASTAS---TTITTMTSGMGPGSSLLDAQW 455
                 ||.||      .:|...||       ||..|.|.:|   |::..:.:..||   :|:   
  Fly   671 YPTNVGGNGGRTVGATEVGAGGNG-------SSAGRTSNSSLGGTSLMKIATIQGP---ILN--- 722

  Fly   456 QSQPPGQTGQVQ-THSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSAN 519
            |||..|....|| ....:..|.         |..|.::|.      :........|.|......|
  Fly   723 QSQAAGGNHMVQKVKPTALKPE---------EPQRNKVRP------FKFAFNRVATPTLNLRFLN 772

  Fly   520 TNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGW 584
            ..||..|....::..|.|.|:.|.:|...|:.||.||||..:|.....|.|..:.:.....|||:
  Fly   773 NRSKRNSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQVPEHVVNTCLWLGY 837

  Fly   585 FNSAINPFIYAFYSVDFRAAFWRL---TCKR 612
            .:|.|||.||..::..|||||.||   .|||
  Fly   838 VSSTINPIIYTIFNRTFRAAFIRLLKCNCKR 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 75/193 (39%)
TM helix 1 118..144 CDD:320189 11/25 (44%)
TM helix 2 151..177 CDD:320189 15/25 (60%)
TM helix 3 189..219 CDD:320189 14/29 (48%)
TM helix 4 232..255 CDD:320189 8/23 (35%)
TM helix 5 272..297 CDD:320189 8/24 (33%)
7tm_GPCRs <533..605 CDD:475119 27/71 (38%)
TM helix 6 539..561 CDD:320189 10/21 (48%)
TM helix 7 573..598 CDD:320189 9/24 (38%)
5-HT2ANP_730859.1 7tm_GPCRs 298..>473 CDD:475119 71/194 (37%)
TM helix 2 321..343 CDD:410628 14/21 (67%)
TM helix 3 359..381 CDD:410628 10/21 (48%)
TM helix 4 404..420 CDD:410628 6/15 (40%)
TM helix 5 443..466 CDD:410628 6/22 (27%)
7tm_GPCRs <779..858 CDD:475119 28/78 (36%)
TM helix 6 792..814 CDD:410628 10/21 (48%)
TM helix 7 826..851 CDD:410628 9/24 (38%)

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