Protein Alignment TyrR and 5-HT1A

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 770
• Identity: 190/770 - (24%)
• Similarity: 277/770 - (35%)
• Gaps: 262/770 - (34%)

  Fly    22 ASSSSLRGLGLGS-----GVGVGGLPENISIVYE------------------DAGNGTGGGGVGG 63
            |||.:|:.:.:.:     .||:|.:..|.:::.|                  |..|||||
  Fly   148 ASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGG----- 207

  Fly    64 VGGGYPSGPNGTDAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIV 128
                                   ..|||      |..|.:     |.....:..:...:....|:
  Fly   208 -----------------------LNVTT------SKVAED-----DFTQLLRMAVTSVLLGLMIL 238

  Fly   129 VTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWI 193
            ||:|||..||.||:..|.|:.:.|..|.|||||||.|...|||......:...|.||..|||||.
  Fly   239 VTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWT 303

  Fly   194 SLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYE 258
            |.|||.||||||.|.||:||||.|||. :.|...|.|.|: .:||..||..|:.::..|..||.:
  Fly   304 SCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRV-FMMIFCVWTAAVIVSLAPQFGWKD 366

  Fly   259 PG---RRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARI-------------SCVIASRHD 307
            |.   |.:.::|..:|:..|.:|:...:|::|:.|::.:|.:|             ..|.|:.::
  Fly   367 PDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNN 431

  Fly   308 NM------TDISVHNKKFK--RYTAA-----------------------------------DVEN 329
            |.      ||..:|..:.:  |::.|                                   |.|.
  Fly   432 NQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEF 496

  Fly   330 ELSEQEQHSSVG---------------------QRQRQATSRT---------------------F 352
            ..|..:..|..|                     ::|.::|:::                     .
  Fly   497 SSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEH 561

  Fly   353 SNQTIAKELQDM-------------------MLSDSDNCAAMGA-------------------GG 379
            ..|...:||:|.                   .....|.|.|.|.                   ..
  Fly   562 GEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKS 626

  Fly   380 AGGGGGGASSATGGTHCQSLLAL-----PSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITT 439
            ...||||.:|.:..|...|:.||     .|.|||                    .|:.|:..:|.
  Fly   627 VKSGGGGGASTSNATTITSISALSPQTPTSQGVG--------------------IAAAAAGPMTA 671

  Fly   440 MTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSL----SQPPRTHSFRHSHGERDRERLRSHHHHPH 500
            .||.:                  |...|:|.|    ::.|.|...|    .|.....:...|...
  Fly   672 KTSTL------------------TSCNQSHPLCGTANESPSTPEPR----SRQPTTPQQQPHQQA 714

  Fly   501 YHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPF 565
            :..|......|:..|.....|.:   ......|:|.|..:||:|:.|.|:.||||||:..|..|.
  Fly   715 HQQQQQQQQLSSIANPMQKVNKR---KETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPL 776

  Fly   566 LAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKP 620
            .|..|.|..:|....|||:|||.:||.||..:|.:||.||     ||....|.:|
  Fly   777 CAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAF-----KRILFGGHRP 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	77/201 (38%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	22/29 (76%)
		TM helix 4	232..255	CDD:320189	7/22 (32%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	33/71 (46%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	76/187 (41%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	13/25 (52%)
		TM helix 3	299..329	CDD:320454	22/29 (76%)
		TM helix 4	340..362	CDD:320454	7/22 (32%)
		TM helix 5	383..412	CDD:320454	7/28 (25%)
		7tm_GPCRs	<743..816	CDD:475119	33/72 (46%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)