Protein Alignment TyrR and chrm2a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_840086.1
• Gene: chrm2a / 352938
• ZFINID: ZDB-GENE-030314-1
• Length: 495
• Species: Danio rerio
• Alignment Length: 561
• Identity: 142/561 - (25%)
• Similarity: 239/561 - (42%)
• Gaps: 140/561 - (24%)

  Fly    96 NESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAV 160
            ||:...|:.:.:..:    :.:.::.|..:..:||||||.||:|:|...|.|:|:.|.|:.|||.
Zfish    15 NETMETADESPYKTV----EVVFIVLVAGSLSLVTVIGNILVMLSIKVNRSLQTVNNYFLFSLAC 75

  Fly   161 ADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYS 225
            |||::|:..|.......:||.|.||.|:||:|::||.::..||:::|..||.|||..||:||:|.
Zfish    76 ADLIIGLCSMNLYTVYIVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLSYP 140

  Fly   226 RKRRSKRLALIMILIVWLLALAITCPPMLGW-YEPGRRDL--REC--RYNQNEGYVIFSAMGSFF 285
            ..|.:| :|.:||...|:|:..:..|.:|.| :..|.|.:  :||  ::..|......:|:.:|:
Zfish   141 VNRTTK-MAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEKECYIQFFSNAAVTFGTAIAAFY 204

  Fly   286 IPMAVMIYVYARISCVIASR--HDNM------TDISVHNKKFKRYTAADVENELSEQEQHSSVGQ 342
            :|:.:|:.:|.::|....||  .||.      .|::..|:..:........|.|:.:|    ..:
Zfish   205 LPVIIMMVLYWQVSRASKSRVKKDNRKPSGGNLDVASSNQIRENSANKPTNNNLTAEE----TDR 265

  Fly   343 RQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGV 407
            .|.|.|..|. ||..|| ||:              |.|.....|.:...|..:|
Zfish   266 GQTQLTDDTI-NQHDAK-LQN--------------GKAPSTASGEAEEAGQANC----------- 303

  Fly   408 GGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLS 472
                           .|:..|.:|..|      |||.|   ::.:.:.::.||.......:.:
Zfish   304 ---------------IPAEEKESSNDS------TSGSG---AVTNQKEEAAPPSSAAANDSQT-- 342

  Fly   473 QPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAG--------VTTTSTSGNTSANTNS------- 522
                  |.||                   ..:||        :.|.|..|:..|.:|:
Zfish   343 ------STRH-------------------RAKAGGSKLTCIKIITKSPKGDCYAPSNATVEIVPA 382

  Fly   523 ----KSLSNRITSLKK------------ENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQA 571
                ..::.:|..:.|            |.|.|:|:..::..|:|.|.|:.:..||..|     .
Zfish   383 VERQNHVARKIVKMTKQPPKKKKAPSSREKKVTRTIMAILVAFVATWTPYNVMVLINAF-----C 442

  Fly   572 SQMLAKAL----TWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            |..:...:    .||.:.||.|||..||..::.|:..|.:|
Zfish   443 SSCIPNTVWTIGYWLCYINSTINPACYALCNITFKKTFKQL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	69/190 (36%)
		TM helix 1	118..144	CDD:320189	11/25 (44%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	23/87 (26%)
		TM helix 6	539..561	CDD:320189	6/21 (29%)
		TM helix 7	573..598	CDD:320189	9/28 (32%)
chrm2a	NP_840086.1	TM helix 6	409..439	CDD:320424	9/29 (31%)
		TM helix 7	448..473	CDD:320424	9/24 (38%)
		7tmA_mAChR_M2	32..480	CDD:320424	137/535 (26%)
		TM helix 1	33..59	CDD:320424	11/25 (44%)
		TM helix 2	66..92	CDD:320424	10/25 (40%)
		TM helix 3	104..134	CDD:320424	13/29 (45%)
		TM helix 4	146..169	CDD:320424	7/23 (30%)
		TM helix 5	191..220	CDD:320424	7/28 (25%)