DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and HTR7

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_062873.1 Gene:HTR7 / 3363 HGNCID:5302 Length:479 Species:Homo sapiens


Alignment Length:589 Identity:145/589 - (24%)
Similarity:228/589 - (38%) Gaps:212/589 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 VGGGYP--SGPNGTDAVA------LTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILI 120
            ||.|.|  |...|.|.||      |......:|..|::...::|:.......|..|   :.:::.
Human    24 VGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRV---EKVVIG 85

  Fly   121 AVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI-GSWQL 184
            ::.....::|:.||.||::::...::||..:|..::|||:|||.|.:.|||......|| |.|..
Human    86 SILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF 150

  Fly   185 GWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAIT 249
            |...|:::|::||:.|||||::||.||:||||.:||||||..::..|.:|. |||.||||:.:||
Human   151 GHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK-MILSVWLLSASIT 214

  Fly   250 CPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISV 314
            .||:.||.: ...|.:.|..:|:.||.|:|...:|:|||:||:::|.:|                
Human   215 LPPLFGWAQ-NVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI---------------- 262

  Fly   315 HNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGG 379
                   |.||                  ::.|....|......:.                   
Human   263 -------YKAA------------------RKSAAKHKFPGFPRVEP------------------- 283

  Fly   380 AGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGM 444
                             .|::||             ||..:|.:  .::..:..|          
Human   284 -----------------DSVIAL-------------NGIVKLQK--EVEECANLS---------- 306

  Fly   445 GPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTT 509
                                                          ||..|..            
Human   307 ----------------------------------------------RLLKHER------------ 313

  Fly   510 TSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQM 574
                             ..|:..|:|.|...||.|:||.|..||||||:.....||:.....|.:
Human   314 -----------------KNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCI 361

  Fly   575 ---LAKALTWLGWFNSAINPFIYAFYSVDFRAAF-------WRLTCKRFFSAG-----------Q 618
               :.:...|||:.||.||||||||::.|.|..:       :|...::..:||           :
Human   362 PLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPE 426

  Fly   619 KPQF 622
            :|:|
Human   427 RPEF 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 76/186 (41%)
TM helix 1 118..144 CDD:320189 5/25 (20%)
TM helix 2 151..177 CDD:320189 11/25 (44%)
TM helix 3 189..219 CDD:320189 17/29 (59%)
TM helix 4 232..255 CDD:320189 12/22 (55%)
TM helix 5 272..297 CDD:320189 11/24 (46%)
7tm_GPCRs <533..605 CDD:475119 33/74 (45%)
TM helix 6 539..561 CDD:320189 12/21 (57%)
TM helix 7 573..598 CDD:320189 13/27 (48%)
HTR7NP_062873.1 7tmA_5-HT7 97..395 CDD:320452 124/476 (26%)
TM helix 2 116..142 CDD:320452 11/25 (44%)
TM helix 3 155..185 CDD:320452 17/29 (59%)
TM helix 4 197..219 CDD:320452 13/22 (59%)
TM helix 5 236..265 CDD:320452 13/51 (25%)
TM helix 6 320..350 CDD:320452 15/29 (52%)
TM helix 7 363..388 CDD:320452 13/24 (54%)

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