DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and HTR6

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000862.1 Gene:HTR6 / 3362 HGNCID:5301 Length:440 Species:Homo sapiens


Alignment Length:547 Identity:139/547 - (25%)
Similarity:191/547 - (34%) Gaps:227/547 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 EPGPTAPVT-TFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTR 145
            ||||||..| .:.....||....         .|    :.|.....|.:|...|:|:|..|.|..
Human     4 EPGPTANSTPAWGAGPPSAPGGS---------GW----VAAALCVVIALTAAANSLLIALICTQP 55

  Fly   146 RLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAI 210
            .||..:|.|::||..:||:||:.|||||:...|.|.|.|...||.:|.:.||:.|:||||:||.|
Human    56 ALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI 120

  Fly   211 SVDRYLAVTRPLTYSRKRRSKRLALIMILIVW-LLALAITCPPMLGWYE--------PGRRDLRE 266
            |:||||.:..||.| :.|.:...||.::|..| |.|||...|.:|||:|        ||     :
Human   121 SLDRYLLILSPLRY-KLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPG-----Q 179

  Fly   267 CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENEL 331
            ||...:..:|:.::..:||:|...:.:.|.||  ::|:|                          
Human   180 CRLLASLPFVLVASGLTFFLPSGAICFTYCRI--LLAAR-------------------------- 216

  Fly   332 SEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHC 396
                         :||..                                    .||..||    
Human   217 -------------KQAVQ------------------------------------VASLTTG---- 228

  Fly   397 QSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPG 461
                                            .||.||.|:                        
Human   229 --------------------------------MASQASETL------------------------ 237

  Fly   462 QTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLS 526
                       |.|||.  |......|..||.:.|.                             
Human   238 -----------QVPRTP--RPGVESADSRRLATKHS----------------------------- 260

  Fly   527 NRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQA-----SQMLAKALTWLGWFN 586
                  :|..|.:.||.|::|.|...|||||:..::       ||     |..|...|||||:.|
Human   261 ------RKALKASLTLGILLGMFFVTWLPFFVANIV-------QAVCDCISPGLFDVLTWLGYCN 312

  Fly   587 SAINPFIYAFYSVDFRAAFWR-LTCKR 612
            |.:||.||..:..||:.|..| |.|.|
Human   313 STMNPIIYPLFMRDFKRALGRFLPCPR 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 73/194 (38%)
TM helix 1 118..144 CDD:320189 7/25 (28%)
TM helix 2 151..177 CDD:320189 13/25 (52%)
TM helix 3 189..219 CDD:320189 17/29 (59%)
TM helix 4 232..255 CDD:320189 9/23 (39%)
TM helix 5 272..297 CDD:320189 5/24 (21%)
7tm_GPCRs <533..605 CDD:475119 29/76 (38%)
TM helix 6 539..561 CDD:320189 10/21 (48%)
TM helix 7 573..598 CDD:320189 12/24 (50%)
HTR6NP_000862.1 7tmA_5-HT6 27..331 CDD:320182 125/505 (25%)
TM helix 1 28..54 CDD:320182 8/29 (28%)
TM helix 2 61..87 CDD:320182 13/25 (52%)
TM helix 3 99..129 CDD:320182 17/29 (59%)
TM helix 4 141..164 CDD:320182 9/22 (41%)
TM helix 5 185..214 CDD:320182 7/30 (23%)
TM helix 6 261..291 CDD:320182 12/36 (33%)
TM helix 7 299..324 CDD:320182 12/24 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..392
Blue background indicates that the domain is not in the aligned region.

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