Protein Alignment TyrR and HTR5A

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 116/507 - (22%)
• Similarity: 187/507 - (36%)
• Gaps: 189/507 - (37%)

  Fly   111 VLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVA 175
            :||..|::::.:....:..|...|.||:..||..|....:.:..|.|:||:|:||...|||.::.
Human    35 LLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLV 99

  Fly   176 VHLIG-SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMIL 239
            ..|.| .||||..||.:||:.|||.|||||.::.||::|||.::||.:.|:.:.| |.::.:||.
Human   100 HELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTR-KCVSNVMIA 163

  Fly   240 IVWLLALAITCPPML-GWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIA 303
            :.|.|:..|:..|:| ||.|.......||:.::...|.:||.:|:|::|:.|:::||
Human   164 LTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVY-------- 220

  Fly   304 SRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSD 368
                           :|.|.||...           ||.|:
Human   221 ---------------WKIYKAAKFR-----------VGSRK------------------------ 235

  Fly   369 SDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTA 433
                                                                             
Human   236 ----------------------------------------------------------------- 235

  Fly   434 STTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHH 498
                   |:.:.|.|..::.:              .|..||....:.||:
Human   236 -------TNSVSPISEAVEVK--------------DSAKQPQMVFTVRHA--------------- 264

  Fly   499 PHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLIT 563
                    ..|....|:|...             :||.:....:.|::|.|:.||:|||:..||:
Human   265 --------TVTFQPEGDTWRE-------------QKEQRAALMVGILIGVFVLCWIPFFLTELIS 308

  Fly   564 PFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFS 615
            | |.......:......|||:.||..||.||..::.::.:||     |.|||
Human   309 P-LCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAF-----KNFFS 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	66/187 (35%)
		TM helix 1	118..144	CDD:320189	6/25 (24%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	7/23 (30%)
		TM helix 5	272..297	CDD:320189	9/24 (38%)
		7tm_GPCRs	<533..605	CDD:475119	23/71 (32%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	107/489 (22%)
		TM helix 1	42..68	CDD:320451	6/25 (24%)
		TM helix 2	75..101	CDD:320451	10/25 (40%)
		TM helix 3	114..144	CDD:320451	16/29 (55%)
		TM helix 4	156..177	CDD:320451	5/20 (25%)
		TM helix 5	197..226	CDD:320451	11/51 (22%)
		TM helix 6	278..308	CDD:320451	11/29 (38%)
		TM helix 7	317..342	CDD:320451	9/24 (38%)