DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and HTR2C

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_000859.2 Gene:HTR2C / 3358 HGNCID:5295 Length:458 Species:Homo sapiens


Alignment Length:559 Identity:132/559 - (23%)
Similarity:206/559 - (36%) Gaps:208/559 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 PTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRT 149
            |.|.:.| :.:|.|....  ..|.|.|.:|..:.::.:    |::|:.||.|||:|:...::|..
Human    29 PVAAIVT-DIFNTSDGGR--FKFPDGVQNWPALSIVII----IIMTIGGNILVIMAVSMEKKLHN 86

  Fly   150 ITNCFVMSLAVADLLVGIFVMPPAVAVHLIG-SWQLGWVLCDIWISLDVLLCTASILSLCAISVD 213
            .||.|:||||:||:|||:.|||.::...|.. .|.|...||.:|||||||..||||:.|||||:|
Human    87 ATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLD 151

  Fly   214 RYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCP-PMLGWYEPGRRDLRE----------C 267
            ||:|:..|:.:|| ..|:..|::.|.|||.:::.::.| |::|        ||:          |
Human   152 RYVAIRNPIEHSR-FNSRTKAIMKIAIVWAISIGVSVPIPVIG--------LRDEEKVFVNNTTC 207

  Fly   268 RYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELS 332
            ..| :..:|:..:..:||||:.:|:..|.....|:                              
Human   208 VLN-DPNFVLIGSFVAFFIPLTIMVITYCLTIYVL------------------------------ 241

  Fly   333 EQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQ 397
                       :|||                :||...                         |.:
Human   242 -----------RRQA----------------LMLLHG-------------------------HTE 254

  Fly   398 SLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQ 462
            .    |.|.....:.|.|....|                                 :..|..|.|
Human   255 E----PPGLSLDFLKCCKRNTAE---------------------------------EENSANPNQ 282

  Fly   463 TGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSN 527
                                   :::..|.:.....|....||                      
Human   283 -----------------------DQNARRRKKKERRPRGTMQA---------------------- 302

  Fly   528 RITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKAL----TWLGWFNSA 588
                :..|.|.::.|.||...|:..|.||||..::: .|.|...:|.|.:.|    .|:|:..|.
Human   303 ----INNERKASKVLGIVFFVFLIMWCPFFITNILS-VLCEKSCNQKLMEKLLNVFVWIGYVCSG 362

  Fly   589 INPFIYAFYSVDFRAAFWR-LTCKRFFSAGQKP---QFP 623
            |||.:|..::..:|.||.. |.|.  :...:||   |.|
Human   363 INPLVYTLFNKIYRRAFSNYLRCN--YKVEKKPPVRQIP 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 73/197 (37%)
TM helix 1 118..144 CDD:320189 8/25 (32%)
TM helix 2 151..177 CDD:320189 15/25 (60%)
TM helix 3 189..219 CDD:320189 21/29 (72%)
TM helix 4 232..255 CDD:320189 7/23 (30%)
TM helix 5 272..297 CDD:320189 7/24 (29%)
7tm_GPCRs <533..605 CDD:475119 24/75 (32%)
TM helix 6 539..561 CDD:320189 9/21 (43%)
TM helix 7 573..598 CDD:320189 10/28 (36%)
HTR2CNP_000859.2 7tmA_5-HT2C 54..385 CDD:341346 119/513 (23%)
TM helix 1 55..81 CDD:341346 9/29 (31%)
TM helix 2 88..114 CDD:341346 15/25 (60%)
TM helix 3 127..157 CDD:341346 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 169..192 CDD:341346 7/22 (32%)
TM helix 5 211..240 CDD:341346 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..301 5/49 (10%)
TM helix 6 304..334 CDD:341346 11/29 (38%)
TM helix 7 347..372 CDD:341346 8/24 (33%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 364..368 2/3 (67%)
PDZ-binding 456..458
Blue background indicates that the domain is not in the aligned region.

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