Protein Alignment TyrR and HTR1F

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000857.1
• Gene: HTR1F / 3355
• HGNCID: 5292
• Length: 366
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 135/501 - (26%)
• Similarity: 200/501 - (39%)
• Gaps: 165/501 - (32%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            |::....:...::|...|:|||.||:.||:|....|..:.||||.|.||.:.|||.::...:..|
Human    24 ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRES 88

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |.:|.|:||||:|:|:..||.|||.|.||::|||.|:|..:.|:|||..|. |.|||.|||::::
Human    89 WIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH-AGIMITIVWIISV 152

  Fly   247 AITCPPMLGWYEPGRRDLRECRYNQNE-GYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMT 310
            .|:.||:. |...|.....||....:. ...|:|..|:|:||:|:::.:|
Human   153 FISMPPLF-WRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY--------------- 201

  Fly   311 DISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAM 375
                    :|.|.||             .....:|||:       .||||
Human   202 --------YKIYRAA-------------KTLYHKRQAS-------RIAKE--------------- 223

  Fly   376 GAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTM 440
                                                        |:.
Human   224 --------------------------------------------EVN------------------ 226

  Fly   441 TSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQP----PRTHSFRHSHGERDRERLRSHHHHPHY 501
                  |..||::..:|.....|..|...|||.|    .:.||...|        |||...|
Human   227 ------GQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRS--------LRSEFKH--- 274

  Fly   502 HHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFL 566
                                .||...:..|..:|.|...||.:::|.|:.||||||:..|:....
Human   275 --------------------EKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC 319

  Fly   567 AEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLT-CK 611
            .:.:.|:.::..|.|||:.||.|||.||..::.||:.||.:|. |:
Human   320 DKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/186 (38%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	10/22 (45%)
		TM helix 5	272..297	CDD:320189	8/25 (32%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
HTR1F	NP_000857.1	7tmA_5-HT1F	24..359	CDD:320456	132/493 (27%)
		TM helix 1	25..51	CDD:320456	7/25 (28%)
		TM helix 2	58..84	CDD:320456	11/25 (44%)
		TM helix 3	96..126	CDD:320456	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	11/22 (50%)
		TM helix 5	178..207	CDD:320456	10/51 (20%)
		TM helix 6	286..316	CDD:320456	13/29 (45%)
		TM helix 7	326..351	CDD:320456	11/24 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)