Protein Alignment TyrR and HTR1E

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000856.1
• Gene: HTR1E / 3354
• HGNCID: 5291
• Length: 365
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 132/491 - (26%)
• Similarity: 199/491 - (40%)
• Gaps: 167/491 - (34%)

  Fly   125 TFIVVTVIG---NTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGW 186
            |.:|:|.:.   |..||:||.||::|....|..:.||||.||||.:.|||.::...::..|:||:
Human    28 TLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGY 92

  Fly   187 VLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCP 251
            .||::|:|:|:..||.|||.||.|::|||.|:|..:.|:|||.:||.|| |||.||.:::.|:.|
Human    93 FLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAAL-MILTVWTISIFISMP 156

  Fly   252 PMLGWYEPGRR---DLRECRYNQNEG-YVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDI 312
            |:  ::...||   ...:|....:.. |.|:|.:|:|:||:.:::.:|.||
Human   157 PL--FWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRI-------------- 205

  Fly   313 SVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGA 377
                                   .|::....|::.:||..||::          :||.|
Human   206 -----------------------YHAAKSLYQKRGSSRHLSNRS----------TDSQN------ 231

  Fly   378 GGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTS 442
                                                                 |.||..:|
Human   232 -----------------------------------------------------SFASCKLT---- 239

  Fly   443 GMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGV 507
                               ||..|...|.|.|  |..|...|.........:...||....|...
Human   240 -------------------QTFCVSDFSTSDP--TTEFEKFHASIRIPPFDNDLDHPGERQQISS 283

  Fly   508 TTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQAS 572
            |                         :|.|..:.|.:::|.||..||||||..||.. |:.:..|
Human   284 T-------------------------RERKAARILGLILGAFILSWLPFFIKELIVG-LSIYTVS 322

  Fly   573 QMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            ..:|..|||||:.||.|||.:|..::.||:.||.:|
Human   323 SEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKL 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	73/185 (39%)
		TM helix 1	118..144	CDD:320189	8/21 (38%)
		TM helix 2	151..177	CDD:320189	12/25 (48%)
		TM helix 3	189..219	CDD:320189	16/29 (55%)
		TM helix 4	232..255	CDD:320189	11/22 (50%)
		TM helix 5	272..297	CDD:320189	8/25 (32%)
		7tm_GPCRs	<533..605	CDD:475119	30/71 (42%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
HTR1E	NP_000856.1	7tmA_5-HT1E	23..355	CDD:320457	129/486 (27%)
		TM helix 1	24..50	CDD:320457	8/21 (38%)
		TM helix 2	57..83	CDD:320457	12/25 (48%)
		TM helix 3	95..125	CDD:320457	16/29 (55%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	119..121		1/1 (100%)
		TM helix 4	137..159	CDD:320457	12/24 (50%)
		TM helix 5	179..208	CDD:320457	10/65 (15%)
		TM helix 6	284..314	CDD:320457	14/54 (26%)
		TM helix 7	323..348	CDD:320457	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	340..344		2/3 (67%)