Protein Alignment TyrR and HTR1D

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 139/519 - (26%)
• Similarity: 202/519 - (38%)
• Gaps: 171/519 - (32%)

  Fly    96 NESAAAAEWAHFYD-LVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLA 159
            |.|..|.|.:..:| ..|....|.|..|.:...:.||:.|..|:..||.||:|.|..|..:.|||
Human    17 NRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLA 81

  Fly   160 VADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY 224
            ..||||.|.|||.::|..:..:|..|.:|||||:|.|:..||||||.||.|::|||.|:|..|.|
Human    82 TTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY 146

  Fly   225 SRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNE-GYVIFSAMGSFFIPM 288
            | |||:...|..||.|||.:::.|:.||:.......:.::.:|..|.:: .|.|:|..|:|:||.
Human   147 S-KRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPS 210

  Fly   289 AVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFS 353
            .::|.:|.||  ..|:|:..:...|::.   ||:|.|.
Human   211 VLLIILYGRI--YRAARNRILNPPSLYG---KRFTTAH--------------------------- 243

  Fly   354 NQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGC 418
                                                            |.:|..|.|: |:.|
Human   244 ------------------------------------------------LITGSAGSSL-CSLN-- 257

  Fly   419 YELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHS 483
                                         |||
Human   258 -----------------------------SSL--------------------------------- 260

  Fly   484 HGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGG 548
                          |..:.|.||  :.....:........:|..:..|..:|.|.|:.|.|::|.
Human   261 --------------HEGHSHSAG--SPLFFNHVKIKLADSALERKRISAARERKATKILGIILGA 309

  Fly   549 FIACWLPFFINYLITPFLAE----HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            ||.||||||:..|:.|...:    |.|   |....||||:.||.|||.||..::.:||.||.::
Human   310 FIICWLPFFVVSLVLPICRDSCWIHPA---LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKI 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	76/186 (41%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	9/25 (36%)
		7tm_GPCRs	<533..605	CDD:475119	32/75 (43%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/5 (40%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	131/496 (26%)
		TM helix 1	40..66	CDD:320455	8/25 (32%)
		TM helix 2	73..99	CDD:320455	13/25 (52%)
		TM helix 3	111..141	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	9/22 (41%)
		TM helix 5	194..223	CDD:320455	11/30 (37%)
		TM helix 6	294..324	CDD:320455	15/29 (52%)
		TM helix 7	335..360	CDD:320455	13/27 (48%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		2/3 (67%)