Protein Alignment TyrR and HTR1B

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 140/547 - (25%)
• Similarity: 212/547 - (38%)
• Gaps: 182/547 - (33%)

  Fly    80 LTEPG----PTAPVTTFNYY---------NESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTV 131
            :.|||    |..|..:..:.         :::.:|.::.:...:.|.|: ::|:.:.|...:.|.
Human     1 MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWK-VLLVMLLALITLATT 64

  Fly   132 IGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLD 196
            :.|..||..:..||:|.|..|..:.||||.||||.|.|||.:....:.|.|.||.|:||.|:|.|
Human    65 LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSD 129

  Fly   197 VLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGR 261
            :..||||||.||.|::|||.|:|..:.||.||..|| |.:||.:||:.:::|:.||.........
Human   130 ITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKR-AAVMIALVWVFSISISLPPFFWRQAKAE 193

  Fly   262 RDLRECRYNQNE-GYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAA 325
            .::.||..|.:. .|.::|.:|:|:.|..::|.:|.||.....||....|.    |:..||.|.|
Human   194 EEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTP----NRTGKRLTRA 254

  Fly   326 DVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSA 390
                                                  .:::||.
Human   255 --------------------------------------QLITDSP-------------------- 261

  Fly   391 TGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQW 455
                                                   .||:|.|        ...|.:.|...
Human   262 ---------------------------------------GSTSSVT--------SINSRVPDVPS 279

  Fly   456 QSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANT 520
            :|..|....||:.            |.|....::::|.:
Human   280 ESGSPVYVNQVKV------------RVSDALLEKKKLMA-------------------------- 306

  Fly   521 NSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAE----HQASQMLAKALTW 581
                        .:|.|.|:||.|::|.||.|||||||..|:.|...:    |.|   :....||
Human   307 ------------ARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLA---IFDFFTW 356

  Fly   582 LGWFNSAINPFIYAFYSVDFRAAFWRL 608
            ||:.||.|||.||...:.||:.||.:|
Human   357 LGYLNSLINPIIYTMSNEDFKQAFHKL 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	73/186 (39%)
		TM helix 1	118..144	CDD:320189	6/25 (24%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	9/22 (41%)
		TM helix 5	272..297	CDD:320189	7/25 (28%)
		7tm_GPCRs	<533..605	CDD:475119	33/75 (44%)
		TM helix 6	539..561	CDD:320189	14/21 (67%)
		TM helix 7	573..598	CDD:320189	11/24 (46%)
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	131/497 (26%)
		TM helix 1	51..77	CDD:320455	6/25 (24%)
		TM helix 2	84..110	CDD:320455	13/25 (52%)
		TM helix 3	122..152	CDD:320455	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	10/23 (43%)
		TM helix 5	205..234	CDD:320455	9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		8/88 (9%)
		TM helix 6	307..337	CDD:320455	17/29 (59%)
		TM helix 7	348..373	CDD:320455	12/27 (44%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		2/3 (67%)