Protein Alignment TyrR and HRH2

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 115/522 - (22%)
• Similarity: 178/522 - (34%)
• Gaps: 221/522 - (42%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            |.:..|.|..|::||.||.:|.||:...||||.:||||::|||:.|||:|:.|:|.:....|...
Human    19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCK 83

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |..|.|.|:|:.||||:|||||||:|..||:|||.||..||.|.......|:|:.::|| |::::
Human    84 WSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVISI 147

  Fly   247 AITCPPM-LGW-----YEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASR 305
            .::...: |||     ...|.....:|:...||.|.:...:.:|::|:.:|...|.||
Human   148 TLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRI------- 205

  Fly   306 HDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSD 370
                         ||
Human   206 -------------FK-------------------------------------------------- 207

  Fly   371 NCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAST 435
                                                      .|::....:...||.|.|:.
Human   208 ------------------------------------------VARDQAKRINHISSWKAATI--- 227

  Fly   436 TITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPH 500
                                                                             
Human   228 ----------------------------------------------------------------- 227

  Fly   501 YHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPF 565
                                             :|:|.|.||:.|:|.||.||.|:|..::....
Human   228 ---------------------------------REHKATVTLAAVMGAFIICWFPYFTAFVYRGL 259

  Fly   566 LAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSA-GQKPQFPTNTMSI 629
            ..:...:::|...:.|||:.|||:||.:||..:.|||..:.:|.|.|..:. ..|....:|...:
Human   260 RGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQL 324

  Fly   630 RR 631
            .|
Human   325 SR 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	58/121 (48%)
		7tm_1	133..>298	CDD:278431	67/170 (39%)
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	109/493 (22%)
		TM helix 1	21..45	CDD:320179	10/23 (43%)
		TM helix 2	54..76	CDD:320179	12/21 (57%)
		TM helix 3	92..114	CDD:320179	14/21 (67%)
		TM helix 4	137..153	CDD:320179	3/16 (19%)
		TM helix 5	180..203	CDD:320179	5/22 (23%)
		TM helix 6	233..255	CDD:320179	11/21 (52%)
		TM helix 7	267..292	CDD:320179	11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		2/11 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870