| Sequence 1: | NP_001287381.1 | Gene: | TyrR / 42136 | FlyBaseID: | FBgn0038542 | Length: | 631 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000852.1 | Gene: | HRH1 / 3269 | HGNCID: | 5182 | Length: | 487 | Species: | Homo sapiens |
| Alignment Length: | 537 | Identity: | 129/537 - (24%) |
|---|---|---|---|
| Similarity: | 221/537 - (41%) | Gaps: | 131/537 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 119 LIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQ 183
Fly 184 LGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAI 248
Fly 249 TCPPMLGW------YEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIAS--R 305
Fly 306 HDNMTDISV----------HNKKFKRYTAADVEN-------ELSEQEQHSSVGQRQRQATSRTFS 353
Fly 354 NQTIAKELQD-MMLSDSDN-------CAAMGAGGAGGGGGGASS---ATGGTHCQSLLALPSGGV 407
Fly 408 GGSMGCAKNGCYELTR------PSSLKRASTASTTITT-----MTSGMGPGSSLLDAQWQSQPPG 461
Fly 462 QTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLS 526
Fly 527 NRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINP 591
Fly 592 FIYAFYSVDFRAAFWRL 608 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TyrR | NP_001287381.1 | 7tm_4 | 127..>249 | CDD:304433 | 51/121 (42%) |
| 7tm_1 | 133..>298 | CDD:278431 | 61/170 (36%) | ||
| HRH1 | NP_000852.1 | 7tmA_Histamine_H1R | 28..479 | CDD:320178 | 127/532 (24%) |
| TM helix 1 | 30..54 | CDD:320178 | 10/23 (43%) | ||
| TM helix 2 | 63..85 | CDD:320178 | 12/21 (57%) | ||
| TM helix 3 | 101..123 | CDD:320178 | 8/21 (38%) | ||
| Important for agonist binding | 107..112 | 1/4 (25%) | |||
| TM helix 4 | 146..162 | CDD:320178 | 4/16 (25%) | ||
| TM helix 5 | 188..211 | CDD:320178 | 4/22 (18%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 238..291 | 9/64 (14%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 345..379 | 6/33 (18%) | |||
| TM helix 6 | 414..436 | CDD:320178 | 8/21 (38%) | ||
| Important for agonist binding | 424..428 | 2/3 (67%) | |||
| TM helix 7 | 447..472 | CDD:320178 | 10/24 (42%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S6630 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.860 | |||||