Protein Alignment TyrR and TAAR6

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_778237.1
• Gene: TAAR6 / 319100
• HGNCID: 20978
• Length: 345
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 109/521 - (20%)
• Similarity: 166/521 - (31%)
• Gaps: 221/521 - (42%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :||..||....|:.|.||.||:::||..::|.:.||..|.|||.||.|||:.|||.::...:...
Human    33 VILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESC 97

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |..|...|......||..|.:|:..||.||:|||:|||.||.|..| .:..::.|.|.:.|:|.|
Human    98 WYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLVYPTK-FTVSVSGICISVSWILPL 161

  Fly   247 AITCPPM-LGWYEPGRRDLRE-------CRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIA 303
            ..:.... .|.|:.|..:|.:       |:...|:.:|:...: |||||..:||.:|..|..
Human   162 MYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWVLTDFL-SFFIPTFIMIILYGNIFL--- 222

  Fly   304 SRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSD 368
                                                |.:||             ||:::
Human   223 ------------------------------------VARRQ-------------AKKIE------ 232

  Fly   369 SDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTA 433
                                                                             
Human   233 ----------------------------------------------------------------- 232

  Fly   434 STTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHH 498
                                                                             
Human   233 ----------------------------------------------------------------- 232

  Fly   499 PHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLIT 563
                            ||.:.|.|.|.|.:....::|.|..:||.:.|..|:..|||:.|:.||.
Human   233 ----------------NTGSKTESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLID 281

  Fly   564 PFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFFSAGQKPQFPTNTMS 628
            .|:. ......:.:...|..::|||:||.|||.:...||.|.      :....||..:..:.||:
Human   282 AFMG-FITPACIYEICCWCAYYNSAMNPLIYALFYPWFRKAI------KVIVTGQVLKNSSATMN 339

  Fly   629 I 629
            :
Human   340 L 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	69/193 (36%)
		TM helix 1	118..144	CDD:320189	12/25 (48%)
		TM helix 2	151..177	CDD:320189	14/25 (56%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	5/23 (22%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	24/71 (34%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
TAAR6	NP_778237.1	7tmA_TAAR6_8_9	33..322	CDD:320439	104/495 (21%)
		TM helix 1	34..60	CDD:320439	12/25 (48%)
		TM helix 2	67..93	CDD:320439	14/25 (56%)
		TM helix 3	105..135	CDD:320439	13/29 (45%)
		TM helix 4	147..170	CDD:320439	5/22 (23%)
		TM helix 5	194..223	CDD:320439	11/68 (16%)
		TM helix 6	251..281	CDD:320439	11/29 (38%)
		TM helix 7	290..315	CDD:320439	9/24 (38%)