DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Htr2a

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_058950.1 Gene:Htr2a / 29595 RGDID:61800 Length:471 Species:Rattus norvegicus


Alignment Length:514 Identity:120/514 - (23%)
Similarity:193/514 - (37%) Gaps:189/514 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVH 177
            :|..::...|    |::|:.||.|||:|:...::|:..||.|:||||:||:|:|..|||.::...
  Rat    75 NWSALLTTVV----IILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTI 135

  Fly   178 LIG-SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIV 241
            |.| .|.|...||.|||.||||..||||:.|||||:|||:|:..|:.:|| ..|:..|.:.|:.|
  Rat   136 LYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSR-FNSRTKAFLKIIAV 199

  Fly   242 WLLALAITCP-PMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASR 305
            |.:::.|:.| |:.|..:..:..........::.:|:..:..:||||:.:|:..|          
  Rat   200 WTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITY---------- 254

  Fly   306 HDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSD 370
                                           ..::...|::||               :.:||..
  Rat   255 -------------------------------FLTIKSLQKEAT---------------LCVSDLS 273

  Fly   371 NCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAST 435
            .                                                         ||..||.
  Rat   274 T---------------------------------------------------------RAKLASF 281

  Fly   436 TITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPH 500
            :..       |.|||                .:..|.|                   ||.|..| 
  Rat   282 SFL-------PQSSL----------------SSEKLFQ-------------------RSIHREP- 303

  Fly   501 YHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPF 565
                         |:.:.....:|:||       |.|..:.|.||...|:..|.||||..::...
  Rat   304 -------------GSYAGRRTMQSISN-------EQKACKVLGIVFFLFVVMWCPFFITNIMAVI 348

  Fly   566 LAEHQASQMLAKAL---TWLGWFNSAINPFIYAFYSVDFRAAFWR-LTCKRFFSAGQKP 620
            ..|.....::...|   .|:|:.:||:||.:|..::..:|:||.| :.|:  :...:||
  Rat   349 CKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQ--YKENRKP 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 69/187 (37%)
TM helix 1 118..144 CDD:320189 9/25 (36%)
TM helix 2 151..177 CDD:320189 14/25 (56%)
TM helix 3 189..219 CDD:320189 21/29 (72%)
TM helix 4 232..255 CDD:320189 7/23 (30%)
TM helix 5 272..297 CDD:320189 7/24 (29%)
7tm_GPCRs <533..605 CDD:475119 21/74 (28%)
TM helix 6 539..561 CDD:320189 9/21 (43%)
TM helix 7 573..598 CDD:320189 8/27 (30%)
Htr2aNP_058950.1 7tmA_5-HT2A 75..391 CDD:341345 114/496 (23%)
TM helix 1 76..102 CDD:341345 10/29 (34%)
TM helix 2 109..135 CDD:341345 14/25 (56%)
TM helix 3 148..178 CDD:341345 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 7/22 (32%)
TM helix 5 231..260 CDD:341345 7/69 (10%)
TM helix 6 316..346 CDD:341345 13/36 (36%)
TM helix 7 359..384 CDD:341345 8/24 (33%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 469..471
Blue background indicates that the domain is not in the aligned region.

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