Protein Alignment TyrR and Adra1a

DIOPT Version :9

• Sequence 1: NP_001287381.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_058887.2
• Gene: Adra1a / 29412
• RGDID: 2055
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 504
• Identity: 133/504 - (26%)
• Similarity: 199/504 - (39%)
• Gaps: 187/504 - (37%)

  Fly   115 QGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI 179
            :.|:|..:....|:..|:||.||||::...|.|.::|:.::::|||||||:...|:|.:....::
  Rat    25 KAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL 89

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYS---RKRRSKRLALIMILIV 241
            |.|..|.|.|:||.::|||.|||||:.||.||:|||:.|:.||.|.   .:||..|    .:|.|
  Rat    90 GYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVR----ALLCV 150

  Fly   242 WLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRH 306
            |:|:|.|:..|:.||.:|...|...|:.|:..|||:|||:|||::|:|:::.:|.|: .|:|.|.
  Rat   151 WVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRV-YVVAKRE 214

  Fly   307 DNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDN 371
                         .|...:.::.:.|:.|          |.|.|.......|:
  Rat   215 -------------SRGLKSGLKTDKSDSE----------QVTLRIHRKNVPAE------------ 244

  Fly   372 CAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTT 436
                        |||.|||...||
  Rat   245 ------------GGGVSSAKNKTH----------------------------------------- 256

  Fly   437 ITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHY 501
                                                                             
  Rat   257 ----------------------------------------------------------------- 256

  Fly   502 HHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFL 566
                                   .|.|:....:|.|..:||.||||.|:.||||||:...|..|.
  Rat   257 -----------------------FSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFF 298

  Fly   567 AEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAF---WRLTCKR 612
            .:.:.|:.:.|.:.|||:.||.|||.||...|.:|:.||   .|:.|.|
  Rat   299 PDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLR 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	54/124 (44%)
		7tm_1	133..>298	CDD:278431	72/167 (43%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	128/490 (26%)
		TM helix 1	29..53	CDD:320448	9/23 (39%)
		TM helix 2	62..84	CDD:320448	9/21 (43%)
		TM helix 3	100..122	CDD:320448	13/21 (62%)
		TM helix 4	145..161	CDD:320448	7/19 (37%)
		TM helix 5	182..205	CDD:320448	11/22 (50%)
		TM helix 6	271..293	CDD:320448	13/21 (62%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		5/14 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010