DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TyrR and adra2da

DIOPT Version :9

Sequence 1:	NP_001287381.1	Gene:	TyrR / 42136	FlyBaseID:	FBgn0038542	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_919345.2	Gene:	adra2da / 266754	ZFINID:	ZDB-GENE-021010-4	Length:	408	Species:	Danio rerio

Alignment Length:	519	Identity:	139/519 - (26%)
Similarity:	216/519 - (41%)	Gaps:	144/519 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 YNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLA 159
            |.|.|:|                |:|.|.:..|::|::||.|||:|:||:|.||...|.|::|||
Zfish    25 YTEPASA----------------IIILVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLA 73

  Fly   160 VADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY 224
            .||:||...|:|.::|..::|.|..|...|..:::||||.||:||:.|||||:|||.:||:.:.|
Zfish    74 CADILVATLVIPFSLANEIMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRY 138

  Fly   225 SRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMA 289
            :.||..:|:. .||.:|||::..|:.||::    ..:.|.:||..|....|::.|...|||.|..
Zfish   139 NLKRTPRRIK-CMIAVVWLISAVISFPPLI----MTKHDEKECLINDETWYILSSCAVSFFAPGL 198

  Fly   290 VMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSN 354
            :||.||.:|                       |..|                   :|.:|..|
Zfish   199 IMITVYCKI-----------------------YRVA-------------------KQRSSTVF-- 219

  Fly   355 QTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCY 419
              :||...:...|.|:.|                                        ..:...:
Zfish   220 --VAKNGLERQPSQSETC----------------------------------------FVRKDKF 242

  Fly   420 ELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSH 484
            |...|||                     :|...||.|.       ::....|.:...:.|  .:.
Zfish   243 EKESPSS---------------------NSSESAQRQE-------ELDDIDLEESAASDS--RAR 277

  Fly   485 GER--DRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVG 547
            |.|  .|.|:......|....:.........|:......|||   ::..: :|.:.|..|::|:|
Zfish   278 GSRFSKRRRVEGERRGPQRSCRVSWAAHQEPGSRQQQLASKS---KVAQM-REKRFTFVLAVVMG 338

  Fly   548 GFIACWLPFFINYLITPFLAEH-QASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC 610
            .|:.||.|||..|.:.....|. ...:.|.|...|:|:.||::||.||..::.|||.||.::.|
Zfish   339 VFVLCWFPFFFTYSLQAVCGERCGPPEALFKLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKVVC 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	56/121 (46%)
TyrR	NP_001287381.1	7tm_1	133..>298	CDD:278431	71/164 (43%)
adra2da	NP_919345.2	7tm_4	45..>183	CDD:304433	61/142 (43%)
		7tm_1	47..386	CDD:278431	122/463 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..306		15/93 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910