Protein Alignment TyrR and adra2a

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_997520.4
• Gene: adra2a / 266750
• ZFINID: ZDB-GENE-021010-1
• Length: 388
• Species: Danio rerio
• Alignment Length: 521
• Identity: 147/521 - (28%)
• Similarity: 223/521 - (42%)
• Gaps: 145/521 - (27%)

  Fly    93 NYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMS 157
            |..|.:.|..|:.....|.||      :|| ...|::.:.||.|||:|:.|:|.||...|.|::|
Zfish     6 NATNGTNATKEYTLLVALPLS------VAV-GLLILLIIFGNVLVIIAVFTSRALRAPQNLFLVS 63

  Fly   158 LAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPL 222
            ||.||:||...|||.::|..|:|.|..|.|.|:|:::||||.|||||..|||||:|||.::|:.:
Zfish    64 LASADILVATLVMPFSLANELMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDRYWSITQAI 128

  Fly   223 TYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIP 287
            .|:.||..:|:..| |.|||::|..|:|||:: ..:....|:  |..|:.:.|::.|.:||||:|
Zfish   129 EYNLKRTPQRIKRI-IFIVWIIAAVISCPPLI-TMKKSEGDI--CDINKEKWYIVSSCIGSFFLP 189

  Fly   288 MAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTF 352
            ..:|:.||.||..:.              ||..|....|        .:.:.||:::.....:..
Zfish   190 CIIMVLVYIRIYQIA--------------KKRTRAPPGD--------HRKNEVGKKENDPHEKLN 232

  Fly   353 SNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNG 417
            ..|....|       |.|...                                  |..|..:.:.
Zfish   233 GIQNAEPE-------DKDEIN----------------------------------GVDMEESSSS 256

  Fly   418 CYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQ-PPRTHSFR 481
            .::::.|.|||:.|:...|                                 .||| .|
Zfish   257 DHKVSNPCSLKKKSSKGKT---------------------------------KLSQIKP------ 282

  Fly   482 HSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVV 546
               |:.|:                    |.....|.| :..|...||      |.:.|..|::|:
Zfish   283 ---GDGDK--------------------TEACQTTKA-SRWKGRQNR------EKRFTFVLAVVI 317

  Fly   547 GGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCK 611
            |.|:.||.|||..|..|.| .:....:.|.|...|.|:.||::||.||..::.|||.:|.::.|:
Zfish   318 GVFVICWFPFFFTYTFTAF-CDCCVPETLFKFFFWFGYCNSSLNPIIYTIFNNDFRRSFKKILCR 381

  Fly   612 R 612
            |
Zfish   382 R 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	80/185 (43%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	11/22 (50%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
adra2a	NP_997520.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..291		23/193 (12%)