Protein Alignment TyrR and Hrh2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001399940.1
• Gene: Hrh2 / 25461
• RGDID: 2831
• Length: 402
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 115/505 - (22%)
• Similarity: 175/505 - (34%)
• Gaps: 228/505 - (45%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :.:..|..|.|::|:.||.:|.||:...||||::||||::|||..|||:|:.|:|.:....|...
  Rat    19 VTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFK 83

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |..|.|.|:|:.||||:|||||||:|..||:|||.|||.||.|.......|:| |.::.:|::::
  Rat    84 WSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVA-ISLVFIWVISI 147

  Fly   247 AITCPPM-LGWYE----PGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRH 306
            .::...: |||..    .|..|..:|:...||.|.:...:.:|::|:.:|...|.||
  Rat   148 TLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRI-------- 204

  Fly   307 DNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDN 371
                        ||                                    ||:|
  Rat   205 ------------FK------------------------------------IARE----------- 210

  Fly   372 CAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTT 436
                                                                  ..||.
  Rat   211 ------------------------------------------------------QAKRI------ 215

  Fly   437 ITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHY 501
                                                                             
  Rat   216 ----------------------------------------------------------------- 215

  Fly   502 HHQAGVTTTSTSGNTSANTNSKSLSNRITSLK----KENKTTQTLSIVVGGFIACWLPFFINYLI 562
                                     |.|:|.|    :|:|.|.||:.|:|.||.||.|:|..::.
  Rat   216 -------------------------NHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVY 255

  Fly   563 TPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL-TCK 611
            .....:...::.:...:.|||:.|||:||.:||..:.|||.|:.:| .||
  Rat   256 RGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCK 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	74/190 (39%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	20/29 (69%)
		TM helix 4	232..255	CDD:320189	4/23 (17%)
		TM helix 5	272..297	CDD:320189	7/24 (29%)
		7tm_GPCRs	<533..605	CDD:475119	27/75 (36%)
		TM helix 6	539..561	CDD:320189	11/21 (52%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
Hrh2	NP_001399940.1	7tmA_Histamine_H2R	19..298	CDD:320179	111/496 (22%)
		TM helix 1	20..46	CDD:320179	9/25 (36%)
		TM helix 2	53..80	CDD:320179	13/26 (50%)
		TM helix 3	91..121	CDD:320179	20/29 (69%)
		TM helix 4	133..153	CDD:320179	4/20 (20%)
		TM helix 5	178..208	CDD:320179	11/85 (13%)
		TM helix 6	226..256	CDD:320179	13/29 (45%)
		TM helix 7	266..291	CDD:320179	10/24 (42%)