DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Adora2a

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_445746.3 Gene:Adora2a / 25369 RGDID:2049 Length:410 Species:Rattus norvegicus


Alignment Length:515 Identity:104/515 - (20%)
Similarity:163/515 - (31%) Gaps:246/515 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 ILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSW 182
            :.|.|.....|:.::||.||..|:.....|:.:||.||:|||.||:.||:..:|.|:.:      
  Rat     5 VYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITI------ 63

  Fly   183 QLGWVL----CDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243
            ..|:..    |..:....::|..:||.||.||::|||:|:..||.|:......| |..:|.|.|:
  Rat    64 STGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVR-AKGIIAICWV 127

  Fly   244 LALAITCPPMLGWYEPGRRD---LRECRYNQNEG-------------YVIFSAMGSF-FIPMAVM 291
            |:.||...|||||....::|   .:.|    .||             |:::....:| .:|:.:|
  Rat   128 LSFAIGLTPMLGWNNCSQKDGNSTKTC----GEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLM 188

  Fly   292 IYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQT 356
            :.:|.||  .:|:|                                                   
  Rat   189 LAIYLRI--FLAAR--------------------------------------------------- 200

  Fly   357 IAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYEL 421
              ::|:.|                                                         
  Rat   201 --RQLKQM--------------------------------------------------------- 206

  Fly   422 TRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQP-PGQTGQVQTHSLSQPPRTHSFRHSHG 485
                                              :||| ||                        
  Rat   207 ----------------------------------ESQPLPG------------------------ 213

  Fly   486 ERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFI 550
                ||.||                                    :|:||....::|:|:||.|.
  Rat   214 ----ERTRS------------------------------------TLQKEVHAAKSLAIIVGLFA 238

  Fly   551 ACWLPFFINYLITPFLA--EHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            .||||..|....|.|.:  .|....::..|:. |...||.:||||||:...:||..|.::
  Rat   239 LCWLPLHIINCFTFFCSTCRHAPPWLMYLAII-LSHSNSVVNPFIYAYRIREFRQTFRKI 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 62/206 (30%)
TM helix 1 118..144 CDD:320189 8/25 (32%)
TM helix 2 151..177 CDD:320189 13/25 (52%)
TM helix 3 189..219 CDD:320189 12/29 (41%)
TM helix 4 232..255 CDD:320189 10/22 (45%)
TM helix 5 272..297 CDD:320189 7/38 (18%)
7tm_GPCRs <533..605 CDD:475119 27/73 (37%)
TM helix 6 539..561 CDD:320189 10/21 (48%)
TM helix 7 573..598 CDD:320189 10/24 (42%)
Adora2aNP_445746.3 7tmA_Adenosine_R_A2A 4..294 CDD:320196 103/510 (20%)
TM helix 1 5..31 CDD:320196 8/25 (32%)
TM helix 2 38..65 CDD:320196 13/32 (41%)
TM helix 3 74..104 CDD:320196 12/29 (41%)
TM helix 4 118..136 CDD:320196 7/17 (41%)
TM helix 5 169..199 CDD:320196 7/31 (23%)
TM helix 6 221..251 CDD:320196 12/29 (41%)
TM helix 7 262..287 CDD:320196 10/25 (40%)
Interaction with GAS2L2. /evidence=ECO:0000269|PubMed:23994616 322..410
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..410
Blue background indicates that the domain is not in the aligned region.

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