Protein Alignment TyrR and Htr4

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_036985.2
• Gene: Htr4 / 25324
• RGDID: 2850
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 134/538 - (24%)
• Similarity: 196/538 - (36%)
• Gaps: 223/538 - (41%)

  Fly   113 SWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTI-TNCFVMSLAVADLLVGIFVMPPAVAV 176
            |.:.::|:..||..|::.::||.||::|:...|:||.| ||.|::|||.|||||.:.|||.. |:
  Rat    16 SVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFG-AI 79

  Fly   177 HLIGS-WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAV-TRPLTYSRKRRSKRLALIMIL 239
            .|:.. |..|.:.|.:..||||||.||||..||.||:|||.|: .:||.|..|....|:|| |:.
  Rat    80 ELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIAL-MLG 143

  Fly   240 IVWLLALAIT-CPPMLGWYEPGRRDLRE------------CRYNQNEGYVIFSAMGSFFIPMAVM 291
            ..|::.:.|: .|.|.||...|..|:.|            |.:..|:.|.|..::.:|:||..:|
  Rat   144 GCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLM 208

  Fly   292 IYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQT 356
            :..|.||                                                        ..
  Rat   209 VLAYYRI--------------------------------------------------------YV 217

  Fly   357 IAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYEL 421
            .|||                                  |.|.:
  Rat   218 TAKE----------------------------------HAQQI---------------------- 226

  Fly   422 TRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGE 486
               ..|:||...|                     :|:|  ||  ...||      ||
  Rat   227 ---QMLQRAGATS---------------------ESRP--QT--ADQHS------TH-------- 249

  Fly   487 RDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIA 551
                |:|:                                        |.|..:||.:::|.|..
  Rat   250 ----RMRT----------------------------------------ETKAAKTLCVIMGCFCF 270

  Fly   552 CWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTC------ 610
            ||.|||:..::.||: ::...:.:..|..|||:.||.:|||:|||.:..||.||..:.|
  Rat   271 CWAPFFVTNIVDPFI-DYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERY 334

  Fly   611 KRFFSAGQKPQFPTNTMS 628
            ||....||.....|.|::
  Rat   335 KRPPILGQTVPCSTTTIN 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	78/201 (39%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	15/25 (60%)
		TM helix 3	189..219	CDD:320189	19/30 (63%)
		TM helix 4	232..255	CDD:320189	8/23 (35%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	27/71 (38%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	124/503 (25%)
		TM helix 1	21..47	CDD:320184	9/25 (36%)
		TM helix 2	55..81	CDD:320184	15/26 (58%)
		TM helix 3	93..123	CDD:320184	19/29 (66%)
		TM helix 4	136..159	CDD:320184	7/23 (30%)
		TM helix 5	189..218	CDD:320184	10/84 (12%)
		TM helix 6	252..282	CDD:320184	12/69 (17%)
		TM helix 7	291..316	CDD:320184	12/24 (50%)