Protein Alignment TyrR and Htr1d

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_036984.1
• Gene: Htr1d / 25323
• RGDID: 2847
• Length: 374
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 136/506 - (26%)
• Similarity: 196/506 - (38%)
• Gaps: 176/506 - (34%)

  Fly   111 VLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVA 175
            ||....|.|:.|.:...:.||:.|..|:..||.|::|.|..|..:.|||..||||.|.|||.::|
  Rat    30 VLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIA 94

  Fly   176 VHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILI 240
            .....:|..|.:|||||:|.|:..||||||.||.|::|||.|:|..|.|| |||:...|..||..
  Rat    95 YTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYS-KRRTAGHAAAMIAA 158

  Fly   241 VWLLALAITCPPMLGWYEPGRRDLRECRYNQNE-GYVIFSAMGSFFIPMAVMIYVYARISCVIAS 304
            ||.:::.|:.||:.........::.:|..|.:: .|.|:|..|:|:||..::|.:|.||  .:|:
  Rat   159 VWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRI--YVAA 221

  Fly   305 RHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDS 369
            |...:...|::.|:|                                    |.|:
  Rat   222 RSRILNPPSLYGKRF------------------------------------TTAQ---------- 240

  Fly   370 DNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAS 434
                                            |.:|..|.|: |:.|
  Rat   241 --------------------------------LITGSAGSSL-CSLN------------------ 254

  Fly   435 TTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHH-- 497
                                                    |..|              .||.|
  Rat   255 ----------------------------------------PSLH--------------ESHTHTV 265

  Fly   498 -HPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYL 561
             .|.:.:|..:....:           .|..:..|..:|.|.|:||.|::|.||.||||||:..|
  Rat   266 GSPLFFNQVKIKLADS-----------ILERKRISAARERKATKTLGIILGAFIICWLPFFVVSL 319

  Fly   562 ITPFLAE----HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            :.|...:    |.|   |....||||:.||.|||.||..::.|||.||.|:
  Rat   320 VLPICRDSCWIHPA---LFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRV 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	74/186 (40%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	9/25 (36%)
		7tm_GPCRs	<533..605	CDD:475119	34/75 (45%)
		TM helix 6	539..561	CDD:320189	13/21 (62%)
		TM helix 7	573..598	CDD:320189	12/24 (50%)
Htr1d	NP_036984.1	7tmA_5-HT1B_1D	32..364	CDD:320455	131/499 (26%)
		TM helix 1	37..63	CDD:320455	8/25 (32%)
		TM helix 2	70..96	CDD:320455	13/25 (52%)
		TM helix 3	108..138	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	150..173	CDD:320455	8/22 (36%)
		TM helix 5	191..220	CDD:320455	11/30 (37%)
		TM helix 6	291..321	CDD:320455	16/29 (55%)
		TM helix 7	332..357	CDD:320455	13/27 (48%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		2/3 (67%)