DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrR and Adra2a

DIOPT Version :9

Sequence 1:	NP_001287381.1	Gene:	TyrR / 42136	FlyBaseID:	FBgn0038542	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_036871.3	Gene:	Adra2a / 25083	RGDID:	2056	Length:	465	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	161/621 - (25%)
Similarity:	241/621 - (38%)	Gaps:	209/621 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LGLGSGVGVGGLPENISIVYEDAGNGTGGGGVGGVGGGYPSGPNGTDAVALTEPGPTAPVTTFNY 94
            |..||...:|.|       ..||||               |..|||:|     ||.....|.
  Rat     8 LAEGSFAPMGSL-------QPDAGN---------------SSWNGTEA-----PGGGTRATP--- 42

  Fly    95 YNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLA 159
                         |.|.::   :.|:.:....::.||.||.|||:|:.|:|.|:...|.|::|||
  Rat    43 -------------YSLQVT---LTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLA 91

  Fly   160 VADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY 224
            .||:||...|:|.::|..::|.|..|.|.|:|:::||||.||:||:.|||||:|||.::|:.:.|
  Rat    92 SADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY 156

  Fly   225 SRKRRSKRLALIMILIVWLLALAITCPPML--------GWYEPGRRDLRECRYNQNEGYVIFSAM 281
            :.||..:|:..| |:.||:::..|:.||::        |..:|..   ..|:.|..:.|||.|::
  Rat   157 NLKRTPRRIKAI-IVTVWVISAVISFPPLISIEKKGAGGGQQPAE---PSCKINDQKWYVISSSI 217

  Fly   282 GSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQ 346
            ||||.|..:||.||.||                       |..|.               :|.|.
  Rat   218 GSFFAPCLIMILVYVRI-----------------------YQIAK---------------RRTRV 244

  Fly   347 ATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGA----GGGGGGASSATGGTHCQSLLALPSGGV 407
            ..||                ...|.|:| ..|||    .|.|....:.|.|...:.|....:|..
  Rat   245 PPSR----------------RGPDACSA-PPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAP 292

  Fly   408 GGSMGCAKNGCYELTRP---SSLKRASTASTTITTMTSGMG------------------PGSSLL 451
            |....         |||   .:|....::|:.......|.|                  ||.||.
  Rat   293 GEPAP---------TRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLP 348

  Fly   452 DAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNT 516
            .....:..||.:|..|....:...:...:|   |.::||:
  Rat   349 RRGPGAAGPGASGSGQGEERAGGAKASRWR---GRQNREK------------------------- 385

  Fly   517 SANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLI------TPFLAEHQASQML 575
                                :.|..|::|:|.|:.||.|||..|.:      .|:        .|
  Rat   386 --------------------RFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPY--------QL 422

  Fly   576 AKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCK 611
            .....|.|:.||::||.||..::.|||.||.::.|:
  Rat   423 FNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_001287381.1	7tm_4	127..>249	CDD:304433	54/121 (45%)
TyrR	NP_001287381.1	7tm_1	133..>298	CDD:278431	72/172 (42%)
Adra2a	NP_036871.3	7tmA_alpha2A_AR	49..452	CDD:320445	139/526 (26%)
		TM helix 1	51..75	CDD:320445	9/23 (39%)
		TM helix 2	84..106	CDD:320445	11/21 (52%)
		TM helix 3	122..144	CDD:320445	13/21 (62%)
		TM helix 4	167..183	CDD:320445	5/16 (31%)
		TM helix 5	209..232	CDD:320445	12/22 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..377		31/160 (19%)
		PRK07764	<243..>365	CDD:236090	30/147 (20%)
		TM helix 6	388..410	CDD:320445	10/21 (48%)
		TM helix 7	420..445	CDD:320445	9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910