Protein Alignment TyrR and Htr1b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_071561.1
• Gene: Htr1b / 25075
• RGDID: 2846
• Length: 386
• Species: Rattus norvegicus
• Alignment Length: 546
• Identity: 140/546 - (25%)
• Similarity: 216/546 - (39%)
• Gaps: 180/546 - (32%)

  Fly    83 PGPTA------PVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAI 141
            |.|.|      |:...::   :.:|.::.:...:.|.|: ::|:|:.|...:.|.:.|..||..:
  Rat    10 PPPPATSQTGVPLANLSH---NCSADDYIYQDSIALPWK-VLLVALLALITLATTLSNAFVIATV 70

  Fly   142 LTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILS 206
            ..||:|.|..|..:.||||.||||.|.|||.:....:.|.|.||.|:||.|:|.|:..|||||:.
  Rat    71 YRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMH 135

  Fly   207 LCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQ 271
            ||.|::|||.|:|..:.||.||..|| |.|||::||:.:::|:.||..........::.:|..|.
  Rat   136 LCVIALDRYWAITDAVDYSAKRTPKR-AAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNT 199

  Fly   272 NEG-YVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQE 335
            :.. |.::|.:|:|::|..::|.:|.||.....||....|.    ||..||.|.|
  Rat   200 DHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTP----NKTGKRLTRA---------- 250

  Fly   336 QHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLL 400
                                        .:::||
  Rat   251 ----------------------------QLITDS------------------------------- 256

  Fly   401 ALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQ 465
                                   |.|       ::::|::.|.:            .:.|.::|.
  Rat   257 -----------------------PGS-------TSSVTSINSRV------------PEVPSESGS 279

  Fly   466 VQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRIT 530
                                             |.|.:|..|           ..:...|..:..
  Rat   280 ---------------------------------PVYVNQVKV-----------RVSDALLEKKKL 300

  Fly   531 SLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAE----HQASQMLAKALTWLGWFNSAINP 591
            ...:|.|.|:||.|::|.||.|||||||..|:.|...:    |.|   :.....|||:.||.|||
  Rat   301 MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMA---IFDFFNWLGYLNSLINP 362

  Fly   592 FIYAFYSVDFRAAFWRLTCKRFFSAG 617
            .||...:.||:.||.:|.  ||...|
  Rat   363 IIYTMSNEDFKQAFHKLI--RFKCTG 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	73/186 (39%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	10/22 (45%)
		TM helix 5	272..297	CDD:320189	7/25 (28%)
		7tm_GPCRs	<533..605	CDD:475119	32/75 (43%)
		TM helix 6	539..561	CDD:320189	14/21 (67%)
		TM helix 7	573..598	CDD:320189	10/24 (42%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	129/497 (26%)
		TM helix 1	47..73	CDD:320455	7/25 (28%)
		TM helix 2	80..106	CDD:320455	13/25 (52%)
		TM helix 3	118..148	CDD:320455	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	142..144		1/1 (100%)
		TM helix 4	160..183	CDD:320455	11/23 (48%)
		TM helix 5	201..230	CDD:320455	9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..276		7/93 (8%)
		TM helix 6	303..333	CDD:320455	17/29 (59%)
		TM helix 7	344..369	CDD:320455	11/27 (41%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	361..365		2/3 (67%)