Protein Alignment TyrR and Gpr101

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001028532.1
• Gene: Gpr101 / 245424
• MGIID: 2685211
• Length: 511
• Species: Mus musculus
• Alignment Length: 512
• Identity: 109/512 - (21%)
• Similarity: 189/512 - (36%)
• Gaps: 82/512 - (16%)

  Fly   116 GIILIAVFATFIVVTVIGNTLVILAILTTRR--LRTITNCFVMSLAVADLLVGIFVMPPAVAVHL 178
            |||...|....:.|..:||  |:|..:..|:  |..:||.|:.:|.|.|||....|.|..|:..:
Mouse    31 GIIRSVVLLVILGVAFLGN--VVLGYVLHRKPNLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAI 93

  Fly   179 IGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWL 243
            ...|.|....|...:||..|...||:.::..:||||||.:..||:|..|..::| :.|::...|:
Mouse    94 PFFWPLNIHFCTALVSLTHLFAFASVNTIVVVSVDRYLTIIHPLSYPSKMTNRR-SYILLYGTWI 157

  Fly   244 LALAITCPPMLGWYE---PGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVI-AS 304
            .|...:.||:.||..   ..|.......:..:..|.:.|.:....||:.|||..|   |.|. |:
Mouse   158 AAFLQSTPPLYGWGHATFDDRNAFCSMIWGASPAYTVVSVVSFLVIPLGVMIACY---SVVFGAA 219

  Fly   305 RHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDS 369
            |.....   ::..|..|......::.:.|.|:    |.::|.             |.||.....
Mouse   220 RRQQAL---LYKAKSHRLEVRVEDSVVHENEE----GAKKRD-------------EFQDKNEFQ- 263

  Fly   370 DNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAS 434
                       |..|||.:.|.|.:   |:...|....|.|.   |.|...|...:.:.....:.
Mouse   264 -----------GQDGGGQAEAKGSS---SMEESPMVAEGSSQ---KTGKGSLDFSAGIMEGKDSD 311

  Fly   435 TTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTH----SLSQPPRTHSFRHSHGERDRERLRSH 495
                .:::|...|..::.....|.....||::..:    .:.:..........|...|.|.:|..
Mouse   312 ----EVSNGSMEGLEVITEFQASSAKADTGRIDANQCNIDVGEDDVEFGMDEIHFNDDVEAMRIP 372

  Fly   496 HHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPF-FIN 559
            ...|                   .:...|.|:.......|.|..:.:.:::..::....|: |:.
Mouse   373 ESSP-------------------PSRRNSTSDPPLPPCYECKAARVIFVIISTYVLSLGPYCFLA 418

  Fly   560 YLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAF----YSVDFRAAFWRLTCKR 612
            .|......:.:..|.:...:.||.:....|:|::|.:    ...:.:....:|.||:
Mouse   419 VLAVWVDIDTRVPQWVITIIIWLFFLQCCIHPYVYGYMHKSIKKEIQEVLKKLICKK 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	57/191 (30%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	12/29 (41%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	11/76 (14%)
		TM helix 6	539..561	CDD:320189	2/22 (9%)
		TM helix 7	573..598	CDD:320189	6/28 (21%)
Gpr101	NP_001028532.1	7tm_GPCRs	33..464	CDD:475119	104/497 (21%)
		TM helix 1	34..58	CDD:410628	6/25 (24%)
		TM helix 2	67..89	CDD:410628	9/21 (43%)
		TM helix 3	105..127	CDD:410628	5/21 (24%)
		TM helix 4	150..166	CDD:410628	3/15 (20%)
		TM helix 5	190..213	CDD:410628	8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..315		20/113 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..386		5/37 (14%)
		TM helix 6	397..419	CDD:410628	2/21 (10%)
		TM helix 7	432..457	CDD:410628	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..511		109/512 (21%)