Protein Alignment TyrR and Chrm2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_987076.2
• Gene: Chrm2 / 243764
• MGIID: 88397
• Length: 466
• Species: Mus musculus
• Alignment Length: 535
• Identity: 136/535 - (25%)
• Similarity: 221/535 - (41%)
• Gaps: 121/535 - (22%)

  Fly   113 SWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVH 177
            :::.:.::.|..:..:||:|||.||:::|...|.|:|:.|.|:.|||.|||::|:|.|.......
Mouse    20 TFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYT 84

  Fly   178 LIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVW 242
            :||.|.||.|:||:|::||.::..||:::|..||.|||..||:||||..||.:| :|.:||...|
Mouse    85 VIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTK-MAGMMIAAAW 148

  Fly   243 LLALAITCPPMLGW-YEPGRRDLR--EC--RYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVI 302
            :|:..:..|.:|.| :..|.|.:.  ||  ::..|......:|:.:|::|:.:|..:|..||...
Mouse   149 VLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRAS 213

  Fly   303 ASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLS 367
            .||          .||.|:...|:                  :...|.:.....|.|...:.|
Mouse   214 KSR----------IKKEKKEPVAN------------------QDPVSPSLVQGRIVKPNNNNM-- 248

  Fly   368 DSDNCAAMGAGGAGGGGG--------GASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRP 424
                        .||.||        |.:...|||                     ..|.:
Mouse   249 ------------PGGDGGLEHNKIQNGKAPRDGGT---------------------ENCVQ---- 276

  Fly   425 SSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDR 489
            ...|.:|..||:::.:.|.|                      :...::|...|.|....|.:.|.
Mouse   277 GEEKESSNDSTSVSAVASNM----------------------RDDEITQDENTVSTSLGHSKDDN 319

  Fly   490 ERLRSHHHHPHYHHQAGVTTTSTS----GNTSANTNSKS--LSNRITSLKK-----------ENK 537
            .|................|.|||:    |::..|.:.|.  ::.:|..:.|           |.|
Mouse   320 SRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKK 384

  Fly   538 TTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFR 602
            .|:|:..::..||..|.|:.:..||..|.|....:.:..... ||.:.||.|||..||..:..|:
Mouse   385 VTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGY-WLCYINSTINPACYALCNATFK 448

  Fly   603 AAFWRLTCKRFFSAG 617
            ..|..|....:.:.|
Mouse   449 KTFKHLLMCHYKNIG 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/190 (37%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	23/82 (28%)
		TM helix 6	539..561	CDD:320189	6/21 (29%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
Chrm2	NP_987076.2	7tmA_mAChR_M2	24..451	CDD:320424	133/517 (26%)
		TM helix 1	25..51	CDD:320424	9/25 (36%)
		TM helix 2	58..84	CDD:320424	11/25 (44%)
		TM helix 3	96..126	CDD:320424	13/29 (45%)
		Important for signaling	120..122		1/1 (100%)
		TM helix 4	138..161	CDD:320424	7/23 (30%)
		TM helix 5	183..212	CDD:320424	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..320		28/180 (16%)
		TM helix 6	380..410	CDD:320424	9/29 (31%)
		TM helix 7	419..444	CDD:320424	9/25 (36%)
		Important for signaling	436..440		2/3 (67%)