DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrR and Drd2

DIOPT Version :10

Sequence 1:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster
Sequence 2:NP_036679.1 Gene:Drd2 / 24318 RGDID:2520 Length:444 Species:Rattus norvegicus


Alignment Length:516 Identity:154/516 - (29%)
Similarity:236/516 - (45%) Gaps:98/516 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 YNESAAAAEWAH--FYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMS 157
            :|.|...|:..|  :|.::|:           ..|.:.|.||.||.:|:...:.|:|.||..::|
  Rat    22 FNGSEGKADRPHYNYYAMLLT-----------LLIFIIVFGNVLVCMAVSREKALQTTTNYLIVS 75

  Fly   158 LAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPL 222
            ||||||||...|||..|.:.::|.|:...:.|||:::|||::||||||:|||||:|||.||..|:
  Rat    76 LAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPM 140

  Fly   223 TYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIP 287
            .|:.:..|||...:||.|||:|:..|:||.:.|.   ...|..|| ...|..:|::|::.||::|
  Rat   141 LYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGL---NNTDQNEC-IIANPAFVVYSSIVSFYVP 201

  Fly   288 MAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTF 352
            ..|.:.||.:|..|:..|...     |:.|:..|...|:::..|.....|.              
  Rat   202 FIVTLLVYIKIYIVLRKRRKR-----VNTKRSSRAFRANLKTPLKGNCTHP-------------- 247

  Fly   353 SNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNG 417
                     :||.|                             |..::             ..||
  Rat   248 ---------EDMKL-----------------------------CTVIM-------------KSNG 261

  Fly   418 CYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRH 482
            .:.:.| ..:..|..|......|.|...|...   .::...||..      |.|:.|..:|...|
  Rat   262 SFPVNR-RRMDAARRAQELEMEMLSSTSPPER---TRYSPIPPSH------HQLTLPDPSHHGLH 316

  Fly   483 SHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVG 547
            |:.:...:..::.|........|......|..|....|:.|::|.|..|.:||.|.||.|:||:|
  Rat   317 SNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLG 381

  Fly   548 GFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            .||.|||||||.:::. ...:.....:|..|.||||:.|||:||.||..::::||.||.::
  Rat   382 VFIICWLPFFITHILN-IHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKI 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 77/185 (42%)
TM helix 1 118..144 CDD:320189 7/25 (28%)
TM helix 2 151..177 CDD:320189 15/25 (60%)
TM helix 3 189..219 CDD:320189 21/29 (72%)
TM helix 4 232..255 CDD:320189 10/22 (45%)
TM helix 5 272..297 CDD:320189 9/24 (38%)
7tm_GPCRs <533..605 CDD:475119 33/71 (46%)
TM helix 6 539..561 CDD:320189 15/21 (71%)
TM helix 7 573..598 CDD:320189 13/24 (54%)
Drd2NP_036679.1 7tmA_D2_dopamine_R 35..438 CDD:320435 148/498 (30%)
TM helix 1 36..62 CDD:320435 9/36 (25%)
TM helix 2 69..92 CDD:320435 14/22 (64%)
TM helix 3 107..137 CDD:320435 21/29 (72%)
TM helix 4 152..170 CDD:320435 8/17 (47%)
TM helix 5 186..211 CDD:320435 9/24 (38%)
Interaction with PPP1R9B. /evidence=ECO:0000269|PubMed:10391935 211..374 41/242 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..329 11/55 (20%)
TM helix 6 367..397 CDD:320435 18/29 (62%)
TM helix 7 406..431 CDD:320435 13/24 (54%)

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