Protein Alignment TyrR and Chrm3

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_036659.2
• Gene: Chrm3 / 24260
• RGDID: 2343
• Length: 589
• Species: Rattus norvegicus
• Alignment Length: 652
• Identity: 167/652 - (25%)
• Similarity: 262/652 - (40%)
• Gaps: 164/652 - (25%)

  Fly    11 SAIYPSLMYVAASSSSLRGLGLGSGVGVGGLPENISIVYEDAGNGTGGGGVGGVGGGYPSGPNGT 75
            |.::|::......|.|..||.||:...:|..  |||   ::.||             :.|....:
  Rat    10 SPLFPNISSSWVHSPSEAGLPLGTVTQLGSY--NIS---QETGN-------------FSSNDTSS 56

  Fly    76 DAVALTEPGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFI-VVTVIGNTLVIL 139
            |.:.    |.|.                          || ::.||....|: :||:|||.|||:
  Rat    57 DPLG----GHTI--------------------------WQ-VVFIAFLTGFLALVTIIGNILVIV 90

  Fly   140 AILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASI 204
            |....::|:|:.|.|::|||.|||::|:..|.......::..|.||.:.||:|:|:|.:...||:
  Rat    91 AFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASV 155

  Fly   205 LSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGW-YEPGRRDL--RE 266
            ::|..||.|||.::||||||..||.:|| |.:||.:.|:::..:..|.:|.| |..|:|.:  .|
  Rat   156 MNLLVISFDRYFSITRPLTYRAKRTTKR-AGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGE 219

  Fly   267 CRYNQ--NEGYVIF-SAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVE 328
            | :.|  :|..:.| :|:.:|::|:.:|..:|.||......|...:..:....      |.|:.|
  Rat   220 C-FIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASG------TEAEAE 277

  Fly   329 NEL----------SEQEQHSSVGQRQRQATSR------TFSNQTIAKEL-QDMMLSDS--DNCAA 374
            |.:          |.:.|...|.:..|:...|      |.|.:..|::: ||...|||  :|.||
  Rat   278 NFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAA 342

  Fly   375 MGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITT 439
            ...         .:||:....              .:|......|.:.    ||.
  Rat   343 ASL---------ENSASSDEE--------------DIGSETRAIYSIV----LKL---------- 370

  Fly   440 MTSGMGPG-SSLLDAQWQSQPPGQTGQVQTHSLSQ---PPRTHSFRHSHGERDRERLRSHHHHPH 500
                  || ||:|::  ...|.....||....|..   ....|..:......|.:..:.......
  Rat   371 ------PGHSSILNS--TKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLP 427

  Fly   501 YHHQAGVTTTSTSG-NTSAN----------------------TNSKSLSNRITSLKKENKTTQTL 542
            ...::.|.|..||. |:||:                      |.|:....:..||.||.|..|||
  Rat   428 IQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTL 492

  Fly   543 SIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKAL----TWLGWFNSAINPFIYAFYSVDFRA 603
            |.::..||..|.|:.|..|:..|     ....:.|..    .||.:.||.:||..||..:..||.
  Rat   493 SAILLAFIITWTPYNIMVLVNTF-----CDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRT 552

  Fly   604 AF 605
            .|
  Rat   553 TF 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	72/192 (38%)
		TM helix 1	118..144	CDD:320189	12/26 (46%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	7/25 (28%)
		7tm_GPCRs	<533..605	CDD:475119	25/75 (33%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	9/28 (32%)
Chrm3	NP_036659.2	7tmA_mAChR_M3	65..>269	CDD:320426	75/206 (36%)
		TM helix 1	69..95	CDD:320426	12/25 (48%)
		TM helix 2	102..129	CDD:320426	10/26 (38%)
		TM helix 3	140..170	CDD:320426	13/29 (45%)
		TM helix 4	182..205	CDD:320426	7/23 (30%)
		TM helix 5	227..256	CDD:320426	9/28 (32%)
		Basolateral sorting signal. /evidence=ECO:0000250	274..280		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..356		11/55 (20%)
		7tm_GPCRs	<483..563	CDD:475119	26/77 (34%)
		TM helix 6	489..511	CDD:320426	9/21 (43%)
		TM helix 7	522..547	CDD:320426	9/24 (38%)